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Molecular Genetics and Emerging Therapies for Epithelial Ovarian Cancer: Basic Research and Clinical Perspectives
Epithelial ovarian cancer (EOC) is the most lethal gynecological disorder due to a lack of effective early detection strategies. Worldwide, approximately 230,000 women are diagnosed annually, whereas 150,000 die. It represents the seventh most commonly diagnosed cancer among women in the world with 5-year survival rate of 46%. More than one-fifth of EOC have been related to hereditary conditions. Considerable efforts have been made to implement screening of the general population to diagnose EOC early; nevertheless, this has been ineffective and there is no approved strategy. Nowadays, new approaches for early diagnosis and prevention based on molecular genomics are in development. Whole gen...
Fertility Preservation in Oncological and Non-Oncological Diseases
This practical book focuses on the most recent advances in fertility preservation in oncological and non-oncological patients. It presents the steps that need to be followed prior to treatment for successful fertility preservation, and describes in detail the medical conditions requiring fertility preservation, including precise information on the risk of fertility loss, prognosis, risk of ovarian metastasis and other possible risks. The book also provides information on how to perform the preservation techniques (success rates, risks, etc.) and on what to do after the treatment (in cases of bleeding during chemotherapy, menopause, wish to conceive, etc.). Written by experts in the field, including members of the globally known network FertiPROTEKT and leading oncologists and specialists, this practical and easy-to-use book is a valuable resource for all clinicians involved in fertility preservation for patients with specific diseases
Sustainability Concept In Developing Countries
Sustainability Concept in Developing Countries is a collection of seven studies addressing the issue of sustainability from the perspective of developing countries. Although it is not a comprehensive review of all developing countries, these contributions do portray some of the major issues in achieving sustainability in many developing countries. The book is divided into two parts: Part 1 includes chapters related to concepts and methodology relevant to sustainability in the context of developing countries. Part 2 presents some actual case studies including descriptions of the situations and advice on how to address sustainability in such economies. This book is a useful reference for professionals in developing countries as well as other jurisdictions.
Agents, Structures and International Relations
The agent-structure problem is a much discussed issue in the field of international relations. In his comprehensive 2006 analysis of this problem, Colin Wight deconstructs the accounts of structure and agency embedded within differing IR theories and, on the basis of this analysis, explores the implications of ontology - the metaphysical study of existence and reality. Wight argues that there are many gaps in IR theory that can only be understood by focusing on the ontological differences that construct the theoretical landscape. By integrating the treatment of the agent-structure problem in IR theory with that in social theory, Wight makes a positive contribution to the problem as an issue of concern to the wider human sciences. At the most fundamental level politics is concerned with competing visions of how the world is and how it should be, thus politics is ontology.
Handbook on the Economics and Management of Sustainable Oceans
The trans-disciplinary thematic areas of oceans management and policy require stocktaking of the state of knowledge on ecosystem services being derived from coastal and marine areas. Recently adopted Sustainable Development Goals (SDGs) especially Goals 14 and 15 explicitly focus on this. This Handbook brings together a carefully chosen set of world-class contributions from ecology, economics, and other development science and attempts to provide policy relevant scientific information on ecosystem services from marine and coastal ecosystems, nuances of economic valuation, relevant legal and sociological response policies for effective management of marine areas for enhanced human well being. The contributors focus on the possible nexus of science-society and science-policy with the objective of informing on decision makers of the governmental agencies, business and industry and civil society in general with respect to sustainable management of Oceans.
Degenerative Spinal Deformity: Creating Lordosis in the Lumbar Spine, An Issue of Neurosurgery Clinics of North America
This issue of Neurosurgery Clinics, edited by Drs. Sigurd Berven and Praveen V. Mummaneni, will cover Degenerative Spinal Deformity: Creating Lordosis in the Lumbar Spine. Topics will include, but are not limited to, Spinopelvic Parameters; Location of lordosis (priority for L4-S1) and Age Adjustments; Approach Selection; Nuances of Pedicle Subtraction Osteotomy; Preventing Pseudarthrosis and PJK; The Challenge of Creating Lordosis in High Grade Dysplastic Spondylolisthesis; Sacropelvic Fixation; Evolution of the MISDEF Algorithm; Transpsoas Approach Nuances; Lateral Prepsoas Approach Nuances; Anterior Column Release; Navigation assisted MIS deformity correction; MIS TLIF; MIS PSO; and The challenge of L4-S1- fractional curves.
The Evolution of Scientific Knowledge
The Evolution of Scientific Knowledge aims to reach a unique understanding of science with the help of economic and sociological theories. The economic theories used are institutionalist and evolutionary. The sociological theories draw from the type of work on social studies of science that have, in recent decades, transformed our picture of science and technology.
The Art of Breaking Bad News Well
As Head of Oncological Surgery and the Gynecology Clinic at Berlin’s Charité Comprehensive Cancer Center, Jalid Sehouli is one of the world’s leading cancer specialists. Every day, he experiences situations in which conversations take on a life-or-death significance. Delivering bad news is one of the most difficult tasks we face in life, especially for professionals such as doctors, police, or crisis intervention personnel, yet it is rarely touched on during training. Over the course of their career, a doctor will hold conversations with around 200,000 patients and their relatives that invariably involve delivering good or bad news. Either way, existential questions will arise, and the way the news is delivered is vital: recent studies show that it has a significant impact on patients’ quality of life and the way they experience treatment. Mixing his wide-ranging professional experience with personal stories, Sehouli describes the emotions and perspectives of those who have to give and receive bad news from a broad perspective. His book can be helpful for anyone who has to deliver bad news—managers, friends, or parents.
Commodity Windfalls, Polarization, and Net Foreign Assets
This paper examines the effect that windfalls from international commodity price booms have on net foreign assets in a panel of 145 countries during the period 1970-2007. The main finding is that windfalls from international commodity price booms lead to a significant increase in net foreign assets, but only in countries that are homogeneous. In polarized countries, net foreign assets significantly decreased. To explain this asymmetry, the paper shows that in polarized countries commodity windfalls lead to large increases in government spending, political corruption, and the risk of expropriation, with no overall effect on GDP per capita growth. The paper's findings are consistent with theoretical models of the current account that have a built-in voracity effect.
