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Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
2015 marks the ten-year anniversary since the First Edition of The Parkinson's Disease Treatment Book was published. This completely updated Second Edition represents a major revision with even more directed treatment guidelines, updated discussions relating to the possible cause(s), and assessments of the current and future role of surgical and innovative strategies.
Scott-Brown's Otorhinolaryngology is used the world over as the definitive reference for trainee ENT surgeons, audiologists and trainee head and neck surgeons, as well as specialists who need detailed, reliable and authoritative information on all aspects of ear, nose and throat disease and treatment. Key points: accompanied by a fully searchable electronic edition, making it more accessible, containing the same content as the print edition, with operative videos and references linked to Medline highly illustrated in colour throughout to aid understanding updated by an international team of editors and contributors evidence-based guidelines will help you in your clinical practice features in...
This work offers a comprehensive and fully updated overview of supportive patient management strategies, highlighting therapeutic approaches other that dopaminergic agents and conventional antiparkinsonian drugs. This second edition: reviews the neuroprotective effects of selegiline on Parkinson's disease; investigates ways of enhancing the effectiveness of levodopa-based therapy; presents methods of speech therapy with well-documented short- and long-term efficacy; and more.
Available as a single volume and as part of the three volume set, Volume One of Scott-Brown's Otorhinolaryngology, Head and Neck Surgery 8e covers Basic Sciences, Endocrine Surgery, and Rhinology. With over 100 chapters and complemented by clear illustrations, the content focuses on evidence-based practice. Clinical coverage is further enhanced by a clear well designed colour page format to ensure easy learning and the esy assimilation of the most up to date material. Definitive coverage in a single volume, with e-version access included.
It is an insidious illness with no known cure, afflicting those who suffer from it with near-uncontrollable tremors, speech impairment, and balance problems. In addition, one's intelligence experiences decline. Among its most prominent victims are Muhammad Ali and Michael J Fox. Parkinson's disease is a disorder of certain nerve cells in the brain that produce dopamine, which is a chemical messenger that the brain uses to help direct and control movement. In Parkinson's disease, these dopamine-producing nerve cells break down, dopamine levels drop, and brain signals directing movement become abnormal. Usually, the disease begins in later life (in one's 50s or after), although there are cases...