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This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the pr...
In this book, a summary and update of the most important areas of CPP research are presented, whilst raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo are discussed. Therapeutic potential of CPPs and commercial developments are discussed. The monograph is written for researchers and students in the field.
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For a meaningful understanding of physics, it is necessary to realise that this corpus of knowledge operates in a register different from natural thought. This book aims at situating the main trends of common reasoning in physics with respect to some essential aspects of accepted theory. It analyses a great many research results based on studies of pupils and students at various academic levels, involving a range of physical situations. It shows the impressive generality of the trends of common thought, as well as their resistance to teaching. The book's main focus is to underline to what extent natural thought is organised. As a result of this mapping out of trends of reasoning, some suggestions for teaching are presented; these have already influenced recent curricula in France. This book is intended for teachers and teacher trainers principally, but students can also benefit from it to improve their understanding of physics and of their own ways of reasoning.
The Terminal Classic in the Maya Lowlands revisits one of the great problems in Mayan archaeology - the apparent collapse of Classic Maya civilization from roughly A.D. 830 to 950. During this period the Maya abandoned their power centers in the southern lowlands and rather abruptly ceased the distinctive cultural practices that marked their apogee in the Classic period. Archaeological fieldwork during the past three decades, however, has uncovered enormous regional variability in the ways the Maya experienced the shift from Classic to Postclassic society, revealing a period of cultural change more complex than acknowledged by traditional models. Featuring an impressive roster of scholars, The Terminal Classic presents the most recent data and interpretations pertaining to this perplexing period of cultural transformation in the Maya lowlands. Although the research reveals clear interregional patterns, the contributors resist a single overarching explanation. Rather, this volume's diverse and nuanced interpretations provide a new, more properly grounded beginning for continued debate on the nature of lowland Terminal Classic Maya civilization.
The Cold War has ended. With a scope and daring not possible until now, an unlikely international alliance of top-level political, financial, and religious interests sees the way clear at last to its ultimate goal: the establishment of a single global society. Utopia. These are men with nothing in common but immense power and a towering ambition for still more. With world unity and prosperity as their slogan--and with betrayal, scandal, and murder as their ready weapons--they have the means and the will to capture as their own the perfect global machinery for their plans: the oldest, wiliest, and most stable political chancery in the world--the Vatican. At the vortex of this lethal struggle ...
Ancient Maya civilization thrived in the tropics of Central America for more than a thousand years and produced some of the world's finest architecture and art. Then it mysteriously vanished, leaving a landscape of ruins smothered by forests. The Classic Maya collapse is one of the great puzzles of history, ranking alongside the Fall of Rome as an enigma that has intrigued scholars for generations.
In agricultural history, specialisation is usually considered as progress, turning peasants into market-orientated farmers and allowing them to escape from self-sufficiency. Recent developments in the field of productivist agriculture and the recent rise of alternative agriculture cast doubt on this conventional concept of agricultural specialisation. Several questions arise: Did specialisation necessarily mean that farms concentrated on a single product? Was it always a great step forward? Did it occur in the same form in earlier centuries as in contemporary economies? The chapters of this book draw attention to several factors relevant to processes of specialisation, such as markets, trans...