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Epigenetics, Energy Balance, and Cancer
This volume of Energy Balance and Cancer provides state-of-the-art descriptions of the rapidly evolving science of epigenetics and how it may explain mechanisms by which alterations in energy balance such as obesity and physical activity may impact cancer. In addition to chapters explaining the processes mediating epigenetic regulation, the volume contains a series of chapters explaining how environmental influences including early life events, nutrition, exercise and microbiota may induce epigenetic changes that can affect carcinogenesis. The following chapters describe epigenetic relations of energy balance to cancer in distinct organ systems including esophagus, colon, prostate and breast. Epigenetics, Energy Balance and Cancer provides a valuable resource for students, research investigators and clinicians seeking to better understand these processes as well as a basis for novel translational and transdisciplinary approaches to further elucidate these processes and develop preventive and therapeutic strategies.
Hand Made
Homemade Shouldn't Be Hectic Do you wish you could slow down and create a home you and your family love and enjoy spending time in? Melissa K. Norris, author of The Made-from-Scratch Life and voice of the Pioneering Today podcast, offers down-to-earth tips and guidance to help you learn how to... bake old-fashioned recipes (everything from biscuits to shepherd's pie) with quick, stress-free steps grow, harvest, and preserve culinary and medicinal herbs (with DIY tutorials for soaps, salves, and balms) make your own cultured and fermented foods at home following simple instructions for buttermilk, sour cream, sourdough, and more simplify your routine and declutter your home with room-by-room guides and Depression-era wisdom Open your heart to God-given rest and discover practical and tangible ways you can craft your home into a refuge for yourself and the ones you love.
The Underlying Mechanisms and Novel Approaches for Diabetes and its Related Complications
Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which severely affects the quality of life and survival of patients. The latest data from the International Diabetes Federation showed that there are approximately 537 million diabetic patients globally in 2021, and it is expected to reach 783 million by 2045. The treatment regime of diabetic patients mainly refers to the management of blood glucose and its complications. At present, typical hypoglycemic medications include insulin and non-insulin hypoglycemic drugs, which can be subdivided into a-glucosidase inhibitors, metformin, thiazolidinediones, sulfonylureas, glinides, DPP-4i, GLP-1RA, and...
Novel Reliable Approaches for Prediction and Clinical Decision-making in Cancer
Cancer is one of the leading causes of death worldwide. Significant advances in the understanding of cancer biology have been reported in the last decade. Many important driving changes, especially immunological deregulations are implicated in cancer development and progression. These events lead to cancer complexity and heterogeneity in cancer and play a substantial role in pharmacokinetic variability in anticancer therapies. Furthermore, it remains difficult to quantify the prevalence of recurrence and metastasis. Interestingly, omics have shown promising results and are being used to better describe cancer susceptibility, prognosis, and response to treatment. Additionally, researchers are...
The Mechanism of Tumor Evolution and Microenvironmental Changes of Genitourinary Oncology in Clinical Diagnosis and Treatment,volume II
Tumor microenvironment (TME) is a bidirectional, dynamic and intricate network of interactions between tumor cells and mesenchymal tissue cells. Therefore, an in-depth study in TME is of great significance for clarifying tumor biology and molecular mechanisms during tumorigenesis and progression. The genitourinary tumors mainly include relatively high-incidence malignant prostate cancer, kidney cancer and bladder cancer, and relatively rare adrenocortical cancer, penile cancer, and so on. There are various complex intercellular communications in genitourinary tumor microenvironment. Many cells reprogram their metabolic pathways to adapt to an acidic hypoxic environment, providing energy support for growth and metastasis of genitourinary tumors. The heterogeneity of genitourinary TME makes tumor progression quite different between individuals. Therefore, it is necessary to analyze the interaction between tumor cells and stromal components, the key components that exert anti-tumor immunity (such as cytotoxic T lymphocytes, TAM, MDSC, etc.) and other genitourinary tumor microenvironment characterizations
Enjoy It All
Diets aren’t sustainable over the long-term, but so many of us don’t know how to eat without food rules to follow. By exploring the many reasons dieting keeps us stuck in an unfulfilling relationship with food— from misguided beliefs about weight and health to social bonding to emotional management — you can finally call off the search for the Secret (hot take: there isn’t one) and learn how to eat according to the wisdom of your body. In her new book Enjoy It All: Improve Your Health and Happiness with Intuitive Eating, Sarah Berneche delivers a step-by-step process for healing your relationship with food and your body image. While nutrition recommendations frequently pepper the p...
