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Volume 26 of 'Progress in Drug Research' contains 10 articles, a subject index for this volume, an alphabetic subject index for volumes 1-26, and an author and subject index for all the volumes which have so far been published. The contributions of volume 26 cover a wide field of drug research and therapy, and some are directed towards tropical deseases. As in previous volumes, the authors have also tried not only to summa rise the current status of particular fields of drug research, but also to provide leads for future research activity. The articles in this volume will be of special value not only to those actively engaged in resolving the diverse problems in drug research, but also to those who wish to keep abrest of the latest developments influencing modern therapy. In addition, it is believed that the 26 volumes of "Progress in Drug Research" now available represent a useful reference work of an encyclo paedic character.
Held at Boppard, Germany, October 3-6, 1984
Hypertension is a major world-wide health problem. With high blood pressure there is a greater risk of stroke, heart attack, heart failure, kidney disease and renal failure. Far too few people realize what the risks are and what can be done to prevent these risks even in the countries where pro grams in hypertension research are active and the full significance of hyper tension is best understood. Some studies of the known hypertensive popu lation indicate that one-half or less are receiving adequate treatment, and, of those on therapy, only half have their high blood pressure satisfactorily controlled. These realizations emphasize the need to inform all segments of society throughout the wo...
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Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
As the life expectancy of patients with arterial hypertension increases, hypertension in the elderly is becoming a relevant medical and social problem. Indeed, epidemiological trials have shown that the cardiovascular risk in elderly hypertensives is significantly higher than in normotensive subjects of comparable age. However, many characteristics of hypertension in the elderly, such as the haemodynamic pattern, do differ greatly from those of younger hypertensives and therefore the results obtained in younger patients cannot be extrapolated to older hypertensives. In this book, experts on hypertension have examined different aspects of hypertension in the elderly: from the changes in the cardiovascular system associated with ageing, to the role of ambulatory blood pressure measurement in the diagnosis of hypertension and the results of the recent clinical trials into the efficacy and tolerability of antihypertensive drugs. This book covers all the clinical aspects of hypertension in the elderly in such a way that it will become a valuable tool for medical students, general practitioners and specialists in hypertension alike.