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Macrolides
Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance.
Free Radical Research in Cancer
Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
Functionalized Nanocarriers for Theranostics
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Proceedings of the Thirteenth Physics Summer School
Bose-Einstein condensation of dilute gases is an exciting new field of interdisciplinary physics. The eight chapters in this volume introduce its theoretical and experimental foundations. The authors are lucid expositors who have also made outstanding contributions to the field. They include theorists Tony Leggett, Allan Griffin and Keith Burnett, and Nobel-Prize-winning experimentalist Bill Phillips. In addition to the introductory material, there are articles treating topics at the forefront of research, such as experimental quantum phase engineering of condensates, the ?superchemistry? of interacting atomic and molecular condensates, and atom laser theory.
Bose-einstein Condensation - From Atomic Physics To Quantum Fluids, Procs Of The 13th Physics Summer Sch
Bose-Einstein condensation of dilute gases is an exciting new field of interdisciplinary physics. The eight chapters in this volume introduce its theoretical and experimental foundations. The authors are lucid expositors who have also made outstanding contributions to the field. They include theorists Tony Leggett, Allan Griffin and Keith Burnett, and Nobel-Prize-winning experimentalist Bill Phillips. In addition to the introductory material, there are articles treating topics at the forefront of research, such as experimental quantum phase engineering of condensates, the “superchemistry” of interacting atomic and molecular condensates, and atom laser theory.
Post-Metropolitan Territories
Processes of multi-scalar regional urbanization are occurring worldwide. Such processes are clearly distinguishable from those of the nineteenth and twentieth centuries due to the shifting concepts of both the city and the metropolis. International literature highlights how what we have historically associated with the idea of cities has long been subjected to consistent reconfiguration, which involves stressing some of the typical features of the idea of "cityness". Post-Metropolitan Territories: Looking for a New Urbanity is the product of a research project funded by the Italian Ministry for Education, Universities and Research (MIUR). It constitutes a thorough overview of a country that ...
Restoration of Amundsen’s lantern slides
The book presents for the first time the restoration of Amundsen’s glass slides, one of the most beautiful collections of slides in the world. The 248 slides are the photographic testimony of three great explorations: the Northwest Passage (1903-1906), the conquest of the South Pole (1910-1912) and the Maud expedition (1918-1925). Discovered by chance in 1986, the slides were restored in 2009 by Pietro Librici at the National Library of Norway, in a continuous cooperation with the institute team. The restoration is presented analytically in its methodological, technical, scientific and operational aspects, constituting an updated model of intervention. Critical historical studies that acco...
Science and Conservation for Museum Collection
The idea of the book “Science and Conservation for Museum Collections” was born as a result of the experience made by CNR-ISTEC (Faenza) in the implementation of a course for Syrian restorers at the National Museum in Damascus. The book takes into consideration archaeological artefacts made out of the most common materials, like stones (both natural and artificial), mosaics, ceramics, glass, metals, wood and textiles, together with less diffuse artefacts and materials, like clay tablets, goldsmith artefacts, icons, leather and skin objects, bones and ivory, coral and mother of pearl. Each type of material is treated from four different points of view: composition and processing technolog...
Self-Commentary in Early Modern European Literature, 1400–1700
This volume investigates the various ways in which writers comment on, present, and defend their own works, and at the same time themselves, across early modern Europe. A multiplicity of self-commenting modes, ranging from annotations to explicatory prose to prefaces to separate critical texts and exemplifying a variety of literary genres, are subjected to analysis. Self-commentaries are more than just an external apparatus: they direct and control reception of the primary text, thus affecting notions of authorship and readership. With the writer understood as a potentially very influential and often tendentious interpreter of their own work, the essays in this collection offer new perspectives on pre-modern and modern forms of critical self-consciousness, self-representation, and self-validation. Contributors are Harriet Archer, Gilles Bertheau, Carlo Caruso, Jeroen De Keyser, Russell Ganim, Joseph Harris, Ian Johnson, Richard Maber, Martin McLaughlin, John O’Brien, Magdalena Ożarska, Federica Pich, Brian Richardson, Els Stronks, and Colin Thompson.
Macrolides
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