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Effects of cell interactions at the endothelium in leukocyte differentiation and polarization during inflammation
A complex exchange of signals between endothelial cells and tissues occurs during steady-state and in inflammatory conditions. These interactions involve numerous cell types including an active contribution from endothelial cells and occur on both sides of the endothelial monolayer. In addition to functioning as selective permeability barriers, it is increasingly recognized that local cell attraction to endothelial cells provides the potential for focal interactions between relevant cells. In this context, cellular interactions taking place at the surface of the endothelium and within the perivascular spaces are thought to initiate crucial steps in the generation and shaping of immune respon...
Role of Metabolism in Regulating Immune Cell Fate Decisions
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Immune Profile after Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: Where Do We Stand?
Autologous hematopoietic stem cell transplantation (AHSCT) was proposed 20 years ago as an alternative therapeutic approach for patients with severe and refractory autoimmune diseases. Since then, this innovative therapy has been successfully used to treat several autoimmune diseases, such as neurological disorders (Multiple Sclerosis), connective tissue diseases (Systemic Sclerosis and Systemic Lupus Erythematous), gastrointestinal inflammatory diseases (Crohn’s Disease) and others (Juvenile Arthritis, Type 1 Diabetes, Vasculitis). Experience in phase I-II and III clinical trials over the years has led to increased safety and efficacy of this procedure. Recent studies have demonstrated su...
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Principles of Mucosal Immunology
Principles of Mucosal Immunology is designed for graduate students and postdoctoral fellows, researchers in immunology and microbiology, and medical and dental students. It presents the basic and clinical aspects of the mucosal immune system, focusing on the major components of the mucosal barrier the gastrointestinal, upper and lower respiratory,
Politie en legitimiteit
Met het begrip ‘legitimiteit van de politie’ wordt de mate van vertrouwen die burgers in de politie hebben en het gezag dat zij aan deze organisatie toekennen, uitgedrukt. Het begrip kent feitelijke elementen (zowel vertrouwen hebben in, accepteren van, als betrouwbaar beoordelen) en normatieve elementen (vinden dat de politie functioneert zoals het hoort en gerechtvaardigd optreedt). Een politie die een grote mate van legitimiteit kent, wordt beter gehoorzaamd en hoeft minder gewelds- en machtsmiddelen in te zetten omdat ze kan volstaan met overtuigen. Er is de politie dan ook veel aan gelegen te zorgen dat ze legitiem functioneert. In dit themanummer gaan we in op de legitimiteit van p...
