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Advanced Techniques in Musculoskeletal Medicine & Physiotherapy is a brand new, highly illustrated guide to the diagnosis and treatment of musculoskeletal disorders. It demonstrates how to safely and effectively use selected minimally invasive therapies in practice. In addition to more well-established techniques such as acupuncture or dry needling, this ground-breaking resource also covers techniques including intratissue percutaneous electrolysis, mesotherapy, percutaneous needle tenotomy, and high volume image guided injections. Other featured chapters include those on specific musculoskeletal ultrasound such as sonoanatomy and ultrasound-guided procedures. Each chapter describes the prin...
Nueva edición renovada y totalmente actualizada de una obra que tiene como objetivo convertirse en una de las referencias internacionales dentro del ámbito de la fisioterapia invasiva. Con una orientación clínica y basada en la evidencia, esta obra se presenta como una guía práctica para el diagnóstico y el tratamiento de las disfunciones del sistema neuromusculoesquelético basado en procedimientos invasivos. Esta nueva edición incorpora nuevos capítulos relacionados con la punción seca segmentaria, la punción seca en hipertonía y espasticidad, la biopuntura, las infiltraciones, las inyecciones volumétricas, el percutaneous needle tenotomy o la termografía, y algunos temas com...
This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The...
Stay current with recent progress in the field of diabetic retinopathy management with this practical resource by Drs. Caroline R. Baumal and Jay S. Duker. Concise, highly illustrated coverage includes summaries of the latest evidence and expert guidance on the rationale for each therapeutic option. - Features a wealth of information for ophthalmologists, retinal specialists, and trainees on current management of this increasingly common condition. - Covers how to select the best course of action between drug, laser, or surgical treatment and how to achieve optimal results. - Includes high-quality images that detail before and after treatment, including OCT. - Consolidates today's available information and guidance on diabetic retinopathy management into one convenient resource.
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
Includes the contribution of James A. Robinson, 2024 Nobel Laureate in Economics Over the past 50 years, scholars across the social sciences have employed critical juncture analysis to understand how social orders are created, become entrenched, and change. In this book, leading scholars from several disciplines offer the first coordinated effort to define this field of research, assess its theoretical and methodological foundations, and use a critical assessment of current practices as a basis for guiding its future. Contributors include stars in this field who have written some of the classic works on critical junctures, as well as the rising stars of the next generation who will continue to shape historical comparative analysis for years to come. Critical Junctures and Historical Legacies will be an indispensable resource for social science research methods scholars and students.
Critical reference explains strategies of microbiome research in humansSummarizes the microbiome's effects on immunity, metabolism, genetics and psychologyEvaluates medical and nutritional therapies for modifying the microbiomeFor healthcare researchers, nutritionists, microbiologists, and medical professionals Written by a team of leading scientists, this book offers a concise technical reference covering human microbiome research and its ramifications for medicine and nutrition. The initial chapters furnish a scientific explanation of the microbiome in general and its ecology. The book then provides a detailed investigation of microbial populations as these pertain to physiology, metabolism and immunology. The final portions are devoted to exploration of the microbiome's effects on chronic and autoimmune diseases and include assessments of clinical therapies and nutritional interventions designed to alter the microbiome to mitigate chronic health conditions.
Of all the parasitic diseases, leishmaniasis is one of the most diverse, with a variety of manifestations, from relatively minor cutaneous lesions to deadly visceral infections. It is also widespread, causing human disease in the Americas, Asia, Europe and Africa. The environments in which this disease occurs range from desert to tropical jungle to urban habitats. Not surprisingly, the literature on this disease is written in a variety of languages including Portuguese, Arabic, English and French among others. This book provides a synopsis in English of much of the recent research on leishmaniasis, with a focus on the epidemiology, diagnosis and treatment of the disease as described by researchers around the world, but with a focus on the research from Brazil and the Middle East.