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Functional Genomics of Wound Healing in Drosophila
La ciencia básica ha de engarzarse con las necesidades sociales. Así, nuestro laboratorio esta involucrado en identificar genes específicamente modulados durante el proceso de cicatrización mediante estudios transcriptómicos en colaboración con diversos grupos. En esta línea, en esta Tesis se han perseguido una serie de objetivos concretos: 1) Realización de un análisis funcional de nuevos genes implicados en cicatrización (discos imaginales). 2) Comparación de los genes identificados en cicatrización en Drosophila con genes identificados en modelos de cicatrización en vertebrados. Más en detalle: ·Estudio y descripción de la cicatrización en discos imaginales de Drosophila ...
From Molecular to Tissue-specific Roles of Fascin During Drosophila Tracheal Development
How a chemoattractant can act on a tissue to induce its migration towards that source? I have tried to answer this question in this research using as migratory tissue model the Drosophila respiratory organ (trachea) during its embryonic development and studying the role of the actin-bundling protein Fascin (called Singed in Drosophila). The tracheal system has been widely used as a model system for tubulogenesis. The formation of tubules is the main organisation of several organs in vertebrates and invertebrates that are essential for life. They allow the exchange of liquid, gas or nutrients to the corresponding target tissues. Some examples are kidney, mammary gland and vascular system in v...
