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This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.
The prevalence of allergic diseases has increased dramatically over recent decades, both in terms of the number of sufferers and the number of allergies. This is a trend that has frequently been referred to as "the epidemic of the 21st century". As described in ancient texts, allergies have been known for over 2,000 years, but the term "allergy" was only coined at the beginning of the 20th century when doctors began to understand their pathophysiological basis. This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights on allergy from antiquity to the 20th century and the development of the associated terminology, it compiles historical ...
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). A/Prof. Menno van Zelm currently serves as the chairman for the IUIS Nomenclature Committee; Prof. Pablo Engel is the chair of the IUIS CD Nomenclature Sub-Committee; Prof. Loems Ziegler-Heitbrock is the chair of the IUIS Monocytes and Dendritic Cells in Blood Sub-Committee; Asst. Prof. Sanny Chan is a member of the WHO / IUIS Allergen Nomenclature Sub-Committee and A/Prof. Andrew Collins is co-chair of the Germline Gene Database (GLDB) Working Group of the Adaptive Immune Receptor Repertoire community (AIRR-C) and chair of the Inferred Allele Review Committee (IARC).
For every summer from 1916 to 1948, Camp Meenahga, on the picturesque shoreline of Lake Michigan in Door County’s Peninsula State Park, hosted young girls and women from across the United States and Canada. From July to September each year, campers slept in canvas tents, told stories beside a massive stone fireplace, swam, canoed, sailed, hiked, rode horses, and watched the sunset from the Lookout, a gazebo with a spectacular view of the waters of Green Bay. With big ideas, little money, and no experience, Alice Orr Clark and Frances Louise “Kidy” Mabley founded Meenahga as a place for young women to refine their manners, enjoy outdoor leisure activities, and learn woodcraft. From the Lookout is an account of these experiences, a history of Camp Meenahga informed by what campers, counselors, and others left behind, including letters home, notes from Clark and Mabley, and many pages from the camp yearbook and newsletter Pack and Paddle. Brimming with nostalgia, From the Lookout brings to life the sights, sounds, and smells of an idyllic summer retreat, one that long after it closed lived on as a place of respite in the memories of those who knew and loved it best.