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Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit th...
Vol. 1,Part I: Initiation: Extracellular and Membrane Events; Vol. 2, Part II: Transmission: Effectors and Cytosolic Events; Vol. 3, Part III: Transcription and Translation: Nuclear and Cytoplasmic Events; Vol. 3, Part IV: Signaling From Intracellular Compartments; Vol. 3, Part V: Cell-Cell and Cell-Matrix Interactions;Vol. 3, Part VI: DISEASE PATHOPHYSIOLOGY: Translational Implications.
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Tanzania has moved from widespread conversion to Islam in the early twentieth century to recent bitter disputes over Islamic radicalism. Using a combination of government, mission and oral records, this volume examines the intellectual and social forces behind these transitions.
Advancing the thesis that a contract between the political members of a community must lead to the highest form of social inclusion, Thomas Hobbes’s Leviathan (1651) has provided the groundwork for democracies around the world. Yet, Hobbes also states that this contract can only be upheld by a strong sovereign whose authority is derived from God. How can a democracy be defined, then, as truly inclusive when it essentially grows out of a theocracy that thinks about human beings in terms of “reduction”? In Democracy and the Divine: The Phenomenon of Political Romanticism Alexandra Aidler argues that despite modern democracy’s problematic heritage, one should not abandon its claims to religion. Articulating a democracy that is based on the religious principle of giving oneself to another, Aidler develops a political theology of democracy that is built upon two traditions in political thought that have rarely been examined thus far side by side for their contributions to this field: German Romanticism, as exemplified by Franz von Baader and Friedrich Schlegel, and the “theological turn” in French philosophy, as represented by Jacques Derrida and Jacques Rancière.
This edited volume addresses memory practices among youth, families, cultural workers, activists, and engaged citizens in Lebanon and Morocco. In making a claim for ‘the social life of memory,’ the introduction discusses a particular research field of memory studies, elaborating an approach to memory in terms of social production and engagement. The Arab Spring is evoked to draw attention to new rifts within and between history and remembrance in the regions of North Africa and the Middle East. As authoritarian forms of governance are challenged, official panoramic narratives are confronted with a multiplicity of memories of violent pasts. The eight chapters trace personal and public inventories of violence, trauma, and testimony, addressing memory in cinema, in newspapers and periodicals, as an experience of public environments, through transnational and diasporic mediums, and amongst younger generations.
This is a review of the current opinions on lipid signalling research with an emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate, but in the light of recent research it has become apparent that any work in this area must include the two, as this book does. In the text, control of synthesis, translocation, and degradation of phosphoinositides is given extensive coverage; there is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation-state of membrane proteins; the regulation of phospholipase C, phospholipase D, the phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth.