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From Oxidative Stress to Cognitive Decline - Towards Novel Therapeutic Approaches
Oxidative stress plays multiple roles in the pathobiology of several neurodegenerative disorders and Alzheimer’s disease in particular. Increased oxidative stress in the brain is suggested to be associated with aging, greater amounts of easily oxidizable unsaturated fatty acids, higher utilization of oxygen by the brain, mitochondrial-derived free radicals, calcium homeostasis, and glutamate-induced excitotoxicity. Moreover, environmental chemicals/toxins, heavy metals, and an imbalanced diet might increase oxidative stress potentially leading to a decrease in cognitive functions. Cellular health is also dependent on the levels of nicotinamide adenine dinucleotide (NAD+). It has been well ...
Ecosystem Services in Patagonia
This book aims to quantify and discuss how societies have directly and indirectly benefited from ecosystem services in Patagonia; not only in terms of provisioning and cultural services, but also regulating and supporting services. Patagonia, a region that stretches across two countries (ca. 10% in Chile and 90% in Argentina), is home to some of the most extensive wilderness areas on our planet. Natural grasslands comprise almost 30% of the Americas, including the Patagonian steppe, while Patagonian southern temperate forests are important for carbon sequestration and storage, play a pivotal role in water regulation, and have become widely recognized for their ecotourism value. However, prof...
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Progenitor Diversity and Neural Cell Specification in the Central Nervous System
The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specializatio...
HIV and Disability
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus qualify for disability benefits. In this report, the Institute of Medicine (IOM) makes several recommendations for improving SSA's capacity for determining disability benefits more accurately and quickly using the HIV Infection Listings.
