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Triumph of the Heart
Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.
Advances in Lipid Research
Advances in Lipid Research, Volume 14 is a five-chapter text that covers other important aspects of lipid chemistry, including an enzyme controlling cholesterol biogenesis, fatty acid activation, and lipid synthesis. The first chapter concerns with the control of activity of ?-hydroxy-?-methylglutaryl coenzyme A reductase. The second chapter deals with the specificity, localization, and function of fatty acid activation. The third chapter describes the interaction between polyene antibiotics and sterols. This chapter specifically tackles some antibiotic activity to understand membrane function and in vivo hypolipidemic activity. The fourth chapter focuses on the lipids in plant cultures, while the fifth chapter looks into the methods of synthesis of acylglycerols and phosphoglycerides. This book will prove useful to lipid chemists, biochemists, and researchers.
University of California, Berkeley
This book "offers an insider's view of the first school in the University of California system. The Beaux-Arts master plan by John Galen Howard created a classic setting for early buildings by Bernard Maybeck, Julia Morgan, and Greene & Greene, and later buildings by John Carl Warnecke, Edward Larrabee Barnes, Charles Moore, Donlyn Lyndon, William Turnbull, and landscape architecture by Lawrence Halprin. The campus is unique for its breadth of architectural works by California designers. [This book], featuring over 100 buildings, is fascinating to read and an easy-to-use companion for a walking tour. With a foreword by Berkeley's Chancellor Robert M. Berdahl, and striking photographs by author Harvey Helfand, this is the definitive guide to the history and architecture of the first public institution of higher learning in California"--Inside front cover.
The Lipoprotein Molecule
The amount of recent information collected about the molecular composition, structure, and function of the plasma lipoproteins, in man as well as in experimental animals, is very large. In this volume an assessment of our knowledge as it stands today has been organized within a framework of four general topics, the first about analytical data, the second about structure, the third about metab olism, and the last about molecular variation and pathology. Thus the analytical, theoretical, experimental, and applied aspects of the topic have been treated in conjunction with each other. The analytical data in human and nonhuman primates were obtained after ultracentrifugal or electrophoretic separ...
