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The essential reference of clinical virology Virology is one of the most dynamic and rapidly changing fields of clinical medicine. For example, sequencing techniques from human specimens have identified numerous new members of several virus families, including new polyomaviruses, orthomyxoviruses, and bunyaviruses. Clinical Virology, Fourth Edition, has been extensively revised and updated to incorporate the latest developments and relevant research. Chapters written by internationally recognized experts cover novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, organized into two major sections: Section 1 provides information regarding broad topics in virology, i...
The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for futu...
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block vira...
Are historians story-tellers? Is it possible to tell true stories about the past? These are just two of the questions raised in this comprehensive collection of texts about philosophy, theory and methodology of writing history.
German memory, judicial interrogation, and historical reconstruction : writing perpetrator history from postwar testimony / Christopher R. Browning -- Historical emplotment and the problem of truth / Hayden White -- On emplotment : two kinds of ruin / Perry Anderson -- History, counterhistory, and narrative / Amos Funkenstein -- Just one witness / Carlo Ginzburg -- Of plots, witnesses, and judgments / Martin Jay -- Representing the Holocaust : reflections on the historians' debate / Dominick LaCapra -- Historical understanding and counterrationality : the Judenrat as epistemological vantage / Dan Diner -- History beyond the pleasure principle : some thoughts on the representation of trauma /...
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In the nineteenth century the United States was ablaze with activism and reform: people of all races, creeds, classes, and genders engaged with diverse intellectual, social, and civic issues. This cutting-edge, revelatory book focuses on rhetoric that is overtly political and oriented to social reform. It not only contributes to our historical understanding of the period by covering a wide array of contexts--from letters, preaching, and speeches to labor organizing, protests, journalism, and theater by white and Black women, Indigenous people, and Chinese immigrants--but also relates conflicts over imperialism, colonialism, women's rights, temperance, and slavery to today's struggles over racial justice, sexual freedom, access to multimodal knowledge, and the unjust effects of sociopolitical hierarchies. The editors' introduction traces recent scholarship on activist rhetorics and the turn in rhetorical theory toward the work of marginalized voices calling for radical social change.
In 1976, a small group of soldiers at Fort Dix were infected with a swine flu virus that was deemed similar to the virus responsible for the great 1918-19 world-wide flu pandemic. The U.S. government initiated an unprecedented effort to immunize every American against the disease. While a qualified success in terms of numbers reached-more than 40 million Americans received the vaccine-the disease never reappeared. The program was marked by controversy, delay, administrative troubles, legal complications, unforeseen side effects and a progressive loss of credibility for public health authorities. In the waning days of the flu season, the incoming Secretary of what was then the Department of Health, Education and Welfare, Joseph Califano, asked Richard Neustadt and Harvey Fineberg to examine what happened and to extract lessons to help cope with similar situations in the future.