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Tumour microenvironment in cancer research and drug discovery
The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.
Membrane Biophysics
This book highlights recent advances in and diverse techniques for exploring the plasma membrane’s structure and function. It starts with two chapters reviewing the history of membrane research and listing recent advances regarding membrane structure, such as the semi-mosaic model for red blood cell membranes and the protein layer-lipid-protein island model for nucleated tissue cell membranes. It subsequently focuses on the localization and interactions of membrane components, dynamic processes of membrane transport and transmembrane signal transduction. Classic and cutting-edge techniques (e.g. high-resolution atomic force microscopy and super-resolution fluorescence microscopy) used in biophysics and chemistry are presented in a very comprehensive manner, making them useful and accessible to both researchers in the field and novices studying cell membranes. This book provides readers a deeper understanding of the plasma membrane’s organization at the single molecule level and opens a new way to reveal the relationship between the membrane’s structure and functions, making it essential reading for researchers in various fields.
Privileged Scaffolds in Drug Discovery
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, ...
Human Model
In Human Model, Dr. Issam Wadi summarises and explains more than 40 years of professional and academic research into human and social behaviour. He examines important aspects in our lives by showing how human and social systems are deeply influenced by universal, natural processes. He shows how research in the natural and social sciences can help to illuminate complex human processes, using friction theory to explain how human beings relate to one another, how resonance theory provides us with a better understanding of mass behaviour, advertising, and marketing, and how feedback theory explains human behaviour from a management perspective. Drawing these parallels between natural and human s...
Catalytic Transformations of Sustainable and Versatile Furanic Chemicals
Diminishing confined fossil resources has spurred the scientific community to strive for alternative, sustainable resources, such as terrestrial biomass, which can potentially substitute fossil-based derivatives. Lignocellulosic biomass is deemed an indispensable carbon source for meeting industrial and social demands regarding energy/fuels and chemicals. Over the past decade, significant advances have been shown in developing a broad spectrum of high-value chemicals and functional materials derived from biomass-based substrates. In connection with this, furanic chemicals, such as 5-hydroxymethylfurfural (HMF) and furfural, have recently received considerable attention due to their potential...
Employment, Retirement and Lifestyle in Aging East Asia
This project offers a comprehensive look at aging policies across East Asia, where a demographic dividend fuelled rapid growth and is now aging into a lower-speed economy. With a comprehensive look at numerous East Asian societies, including China, Japan, Korea, and other regions, the book is rich in comparative insights and strategies into what is effective for policymakers and employers. As the Asian century begins, this book will be an invaluable resource for economists, policymakers and demographers.
Materials Science and Intelligent Technologies Applications
Selected, peer reviewed papers from the 2014 3rd International Conference on Key Engineering Materials and Computer Science (KEMCS 2014), August 5-6, 2014, Singapore
Immunity and Inflammatory Responses in Kidney Disease: from Mechanisms to Novel Therapeutic Strategies
Kidney disease is a leading cause of death worldwide and is increasingly recognized as a global health problem. The kidneys are a frequent target of systemic immune and autoimmune disorders, including systemic autoimmunity and vasculitis, immune complex-related serum sickness, and complement disorders. The complex regulation between the immune system and inflammation plays a key role in the progression of kidney disease, especially in immune-related nephropathy. Cytokines released by monocytes/macrophages, including IL-17, INF-γ, TNF, and IL-6, exacerbate renal dysfunction and injury. M1 pro-inflammatory cells help to clear infections but can also promote renal injury and lead to renal fibr...
Quantitative Economics In China: A Thirty-year Review
This book provides a comprehensive overview of the fruitful achievement of China's Quantitative Economics during the past 30 years, assembling pioneering contributions of prominent quantitative economists in China. It chronicles significant events and the detailed evolution of Quantitative Economics in China. This well-organized book is a must-have for scholars to get a full picture of the status quo, and identify possible research gaps.
