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In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty acid-activated transcription factors as well as membrane and soluble fatty acid transporters, covering such aspects as structure and function, lipid-protein interaction, delivery of ligands, and the roles of these proteins in gene expression pertaining to the homeostatic and diseased states of cells and organs. Incorporating recent findings, this is indispensable for basic scientists, health professionals in industry and clinics as well as postgraduate students. Contributors among others: N.A. Abumrad, J.E. Schaffer, G. Schmitz, N.J. Brunskill, J. Storch, U. Seedorf, S. Mandrup, C.N.A. Palmer, T. Perlmann, H.I. Nebb, J. Bar-Tana, H. Kondo, C. Wolfrum, C. Kerkhoff , S. Farmer, E.J. Murphy, J.F.C. Glatz, P. Besnard, J.M. Stewart, A. Meirhaeghe, J. Plutzky, W. Wahli, R.A. Roberts
Challenging and provocative overviews are presented in Volume 40 of Current Topics in Membranes. Topics on cell lipids vary from basic themes such as biosynthesis and membrane distribution to the role of lipids in intracellular signaling and membrane flow. This single volume also highlights the roles of lipids in eukaryotic cells and discusses organization of lipids in microdomains.
Ether Lipids: Biochemical and Biomedical Aspects is a 21-chapter text that explores the procedures for the analysis, synthesis, and biomedical application of ether lipids. This book surveys first the chromatographic analysis of ether lipids and their characterization by mass spectrometry. The following chapter describes the chemical synthesis of lipids containing alkyl or 1-alkenyl chains. Three chapters are devoted to the biosynthesis of ether lipids, and four others cover unusual ether lipids. Significant chapters focus on biologically active ether lipids, including the naturally occurring platelet-activating factor and synthetic alkyl analogs of lysophosphatidylcholines, which exhibit cancerostatic properties. This text further discusses the application of these and related substances in biomedical research as well as in clinical diagnosis and therapy. The remaining chapters highlight the use of ether lipids in studies aimed at elucidating the structure of membranes and their functions. Organic chemists, biochemists, and researchers in the biomedical field will find this book invaluable.
Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fourth edition of the Handbook of Biochemistry and Molecular Biology represents a dramatic revision — the first in two decades — of one of biochemistry's most referenced works. This edition gathers a wealth of information not easily obtained, including information not found on the web. Offering a molecular perspective not available 20 years ago, it provides physical and chemical data on proteins, nucleic acids, lipids, and carbohydrates. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the mo...
These Proceedings contain both oral and poster contributions to the first interna tional conference" Field Screening Europe - Strategies and Techniques for On-Site Investigation and Monitoring of Contaminated Soil, Water and Air", held in Karls ruhe September 29 - October 1, 1997. Environmental monitoring and the assessment of chemical contaminations are be coming more and more important. The integrated study of environmental con tamination in the field is a rather recent approach. "Field screening" indicates such field analytical tools, (quick) methods and strategies for on-site or in-situ environmental analysis and assessment of contamination. The classical strategy for investigating conta...
In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.
This volume deals with the intellectual Huguenot Refuge (ca 1680–1780), discussing its philosophical, theological, historical, and literary aspects in European context. It uses Berlin as its regional point of departure: In the French-Protestant community of Berlin, the erudites rapidly established networks which pursued a very wide range of interest, communicating with every Protestant scholar who might contribute to the dissemination of Enlightened thought. The first part of the book, therefore, introduces the biggest and most complex centre of the Refuge in Germany. Whereas the second and third part examine different fields of knowledge, the fourth focusses on the topic of dissemination. All contributions present new material–be it on 'Huguenot' hermeneutics, journalism, history, or on the relationship between Berlin and the United Provinces. Contributors include: Lutz Danneberg, Joris van Eijnatten, Herbert Jaumann, John Christian Laursen, Fabrizio Lomonaco, Martin Mulsow, Fiammetta Palladini, Sandra Pott, and Annett Volmer.
This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Qualitative Analysis and Quantitative Assessment of Changes in Neutral Glycerol Lipid Molecular Species within Cells; Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry; Detection and Quantitation of Eicosanoids via High Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry; Structure-specific, quantitative methods for "lipidomic" analysis of sphingolipids by tandem mass spectrometry; Analysis of Ubiquinones, Dolichols and Dolichol Diphospha...