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Drug-protein Binding
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Inverse Agonism
This volume reflects the current state of thinking and debates with regard to inverse agonism. It constitutes the first book published on this issue and holds the contributions and recorded discussions of the 10th Esteve Foundation Symposium held in 2002. Inverse agonism at G-protein-coupled receptors is a novel pharmacological concept with important consequences for the understanding of receptor mechanisms and drug action. Since its first description in 1989 the concept of inverse agonism has dramatically changed the view on current and future medicines. Next to traditional agonists and antagonists the drug repertoire has been expanded now with a novel category of ligands, i.e. 'inverse agonists'.
Molecular Biology and Pharmacology of Tissue Repair
Diseases associated with impaired tissue repair are common clinical problems. Therefore, the elucidation of the molecular basis of normal and impaired repair will help to define new therapeutic targets to alleviate and eventually cure these illnesses. Furthermore, recent studies have revealed remarkable similarities between tissue repair and cancer at the cellular and molecular level. Thus, the characterization of the mechanisms underlying normal repair processes will also enhance our knowledge on the pathogenesis of cancer and provide the basis for the development of novel cancer therapeutics. In recent years, our understanding on the molecular and cellular mechanisms involved in tissue rep...
Optimal Dose Identification
These proceedings provide a general update in an important area of clinical pharmacology; describing how individual subjects vary in their response to drugs and how this information can be used to optimise drug dosing in disease. These proceedings cover areas such as the relevance of studies at various stages of drug development, in optimising drug dosing, the role that pharmacokinetics and pharmacodynamics play and how molecular biology has an increasingly important role in this area. As examples of how these influences may play a role, consideration is given to how drug dosing is optimised in various diseases such as cancer, psychiatric and cardiovascular disease, as well as considering the role that age may play in predicting drug dose. The major theme of this volume is that choosing the optimal dose of a drug has never been more important as risk and benefits must be carefully assessed. There are a series of underlying principles which help determine the optimal dose, and these are dealt with in a systematic manner, using relevant disease states to illustrate these principles.
Drug Tranport(ers) and the Diseased Brain
There are many potent drugs available for many diseases of the brain (e.g. Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Stroke, Brain tumors) The effectiviness however is not optimal since barriers in the brain prevent the drugs from reaching the brain in sufficient therapeutic concentrations (e.g. the blood-brain barrier and the blood-cerebrospinal fluid barrier). Drug Transport(ers) and the Diseased Brain contains the papers of a timely symposium held in Spain between 6 and 9 October 2004, which sets out not only the point of view of the academic researcher and the clinician, but also from the pharmaceutical industrial on how to overcome these barriers and how to treat brain diseases effectively. Blood-brain barrier and blood-cerebrospinal fluid-barrier drug transport; Drug targeting to the brain; Drug transporters at barriers in the brain
The Pharmacology of Cell Differentiation
The proceedings of the Esteve Foundation Symposium V, held in Mallorca in 1992, provide a progress report on work in cancer therapy, one of the frontiers of contemporary pharmacology. It includes chapters on the role of Ras proteins in T-cell activation and the design of differentiation therapies.
