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This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. - Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broa...
The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. • Applies analytical techniques to natural products research – an area of critical importance to drug discovery • Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics • Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail for both current practitioners and beginning researchers
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Walker's vision, the text smoothly combines in-depth scholarship with a popular, readable style to preserve and enhance what the Washington Post called a "landmark of zoological literature."
Widely recognized as the gold standard reference in the field, Green's Operative Hand Surgery, 8th Edition, provides complete coverage of the surgical and nonsurgical management of the full range of upper extremity conditions. In a clearly written and well-illustrated format, it contains both foundational content for residents and fellows as well as new approaches, case-based controversies, and outcomes-based solutions for practitioners. Drs. Scott W. Wolfe, William C. Pederson, Scott H. Kozin, and Mark S Cohen, along with new, international contributing authors, provide expert perspectives and preferred methods for all aspects of today's hand, wrist, and elbow surgery. - Contains thoroughly...
Planet Without Apes demands that we consider whether we can live with the consequences of wiping our closest relatives off the face of the Earth. Leading primatologist Craig Stanford warns that extinction of the great apes—chimpanzees, bonobos, gorillas, and orangutans—threatens to become a reality within just a few human generations. We are on the verge of losing the last links to our evolutionary past, and to all the biological knowledge about ourselves that would die along with them. The crisis we face is tantamount to standing aside while our last extended family members vanish from the planet. Stanford sees great apes as not only intelligent but also possessed of a culture: both too...