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Resolving Colistin Resistance and Heteroresistance in Enterobacter Species
Abstract: Species within the Enterobacter cloacae complex (ECC) include globally important nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter xiangfangensis as the most common species (65.5%) detected, a result replicated by examining a global pool of 3246 isolates. Antibiotic resistance profiling revealed widespread resistance and heteroresistance to the antibiotic colistin and detected the mobile colistin resistance (mcr)−9 gene in 19.2% of all isolates. We show that resistance and heteroresistance properties depend on the chromosomal arnBCADTEF gene cassette whose products catalyze transfer of L-Ara4N to lipid A. Using comparative genomics, mutational ana...
Infectious Disease Epidemiology
Infectious Disease Epidemiology provides a concise reference for practicing epidemiologists, and provides trainee readers with a thorough understanding of basic the concepts which are critical to understanding specialist areas of infectious disease epidemiology. Divided into two sections, part one of the book covers a comprehensive list of methods relevant to the study of infectious disease epidemiology, organised in order of increasing complexity, from a general introduction, to subjects such as mathematical modelling and sero-epidemiology. Part two addresses major infectious diseases that are of global significance due to their current burden or their potential for causing morbidity and mortality. The examples have been selected and grouped into chapters based on the route of transmission. This practical guide will be essential reading for postgraduate students in infectious disease epidemiology, health protection trainees.
Gene Vaccines
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
Vaccines
This publication contains a number of papers which consider the public health role of vaccines in improving the health of the world's populations, and looks at the challenges of using immunisation to combat emerging and re-emerging diseases. Issues discussed include the innovative use of vaccines against diseases such as meningococcal infection in Africa, Haemophilus influenza type b, varicella, and hepatitis, efforts to develop a new generation of vaccines against cholera and typhoid, shigella and Helicobacter pylori, as well as developments in the quest for vaccines against tuberculosis, HIV/AIDS, dengue, malaria, and hookworm. It also deals with the use of vaccines to fight bioterrorism attacks; regulatory and safety issues; financing issues, impact of health sector reform and the sustainability of immunisation programmes.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Ultra-Wideband Radio Technologies for Communications, Localization and Sensor Applications
Ultra-Wideband Radio (UWB) earmarks a new radio access philosophy and exploits several GHz of bandwidth. It promises high data rate communication over short distances as well as innovative radar sensing and localization applications with unprecedented resolution. Fields of application may be found, among others, in industry, civil engineering, surveillance and exploration, for security and safety measures, and even for medicine. The book considers the basics and algorithms as well as hardware and application issues in the field of UWB radio technology for communications, localization and sensing based on the outcome of DFG's priority-funding program "Ultra-Wideband Radio Technologies for Communications, Localization and Sensor Applications (UKoLoS)".
Hemodynamic Monitoring
This book, part of the European Society of Intensive Care Medicine textbook series, teaches readers how to use hemodynamic monitoring, an essential skill for today’s intensivists. It offers a valuable guide for beginners, as well as for experienced intensivists who want to hone their skills, helping both groups detect an inadequacy of perfusion and make the right choices to achieve the main goal of hemodynamic monitoring in the critically ill, i.e., to correctly assess the cardiovascular system and its response to tissue oxygen demands. The book is divided into distinguished sections: from physiology to pathophysiology; clinical assessment and measurements; and clinical practice achievemen...
