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Human Gene Evolution
The story of our evolutionary past is told in our genome sequence. Human Gene Evolution deals with the origins of human genes, describes their structure, function, organisation and expression. The text integrates our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms underlying evolutionary change.
Anticarcinogenesis and Radiation Protection 2
The dramatic decrease in the incidence of stomach cancer in industrialized countries during the past 50 years, which is yet to be fully explained, and the observation that carcinogenesis in laboratory animals can be inhibited by antioxidants, retinoids, and caloric restriction, among other influences, challenge us to press on in the search for practical means to prevent cancer. It is in relation to this goal that the studies summarized in this book have special significance. This book is based on the invited and contributed papers presented at the Third Internationai Conference on Anticarcinogenesis and Radiation Protection, held on October 15-21, 1989, in Dubrovnik, Yugoslavia. They cover a...
The Legacy of Cell Fusion
In order to study the genetics of somatic animal cells, Henry Harris and his colleagues invented the powerful method of viral-induced animal cell fusion. This volume evaluates the impact of cell hybridization on the study of cell differentiation, gene mapping, gene regulation, and the development of monoclonal antibodies. The book details important studies on nuclear structure and function, intracellular transport, membrane protein mobility, and nuclear-cytoplasmic interactions in heterokaryons and other cells. Tumor-suppressor genes and the role of radiation-hybrid mapping in the analysis of genetic tumors are also discussed. The book concludes with a chapter by Henry Harris which addresses a number of unsolved questions that remain regarding the link between cell growth and differentiation. Students and researchers in molecular genetics and cell, molecular, and cancer biology will welcome this fascinating overview of cell fusion research.
Drosophila Cells in Culture
Currently Drosophila is a dominant experimental model in developmental biology and in gene regulation in eukaryotes. This volume summarizes some thirty years of experience in the handling of in vitro cultured Drosophila cells. Its main emphasis is on gene transfer methodology, cell responses to heat shock, hormonal regulation of genes, and on the expression and mobility of transposable elements. - Some thirty years of experience in handling in vitro cultured Drosophila cells - Cell cultures which provide material for a multiplicity of biochemical approaches - DNA-mediated gene transfer as an irreplaceable tool for analyzing basic mechanisms of regulation - Drosophila cell lines which qualify them for use in biotechnology
Principles of Molecular Oncology
At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
