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Neurodegenerative Diseases: From Gut-Brain Axis to Brain Microbiome
While there are growing line of evidence for the role of the gut microbiome in different neurodegenerative diseases, the role and even the existence of the brain microbiome is only starting to be uncovered. Indeed, the brain was long considered to be a sterile environment and only recent studies have shown the presence of bacteria and fungi in the human central nervous system, and even inhabiting brain cells. The so called “brain microbiome” is appealing and immediately drew attention, since it is highly possible that microorganisms could have profound direct effects on a variety of processes in the brain, with the non-limiting examples of neurodegenerative and neurodevelopmental diseases triggering and progression. However, the brain microbiome remains poorly understood and even despite recent technological advances, is has only began to be explored.
Antimicrobial Resistance
Antimicrobial resistance has existed in nature long before the discovery of antibiotics. The mechanisms of resistance are prevalent among the bacterial population. Over a period of time and facilitated by indiscriminate usage of antibiotics, these mechanisms are transferred from one type of bacteria to another, including the pathogenic ones. In addition, the rate of discovery of novel antimicrobials is much slower than the rate of evolution of antimicrobial resistance. Therefore, there is a need for alternative strategies to control antimicrobial resistance to save lives. In this book, the novel strategies to combat antimicrobial resistance are described, emphasizing collaborative measures of control. We describe the concerted efforts undertaken by global communities to combat antimicrobial resistance in detail. The most efficient strategy could be a behavioral change towards indiscriminate consumption, usage, and prescription of antibiotics.
Alzheimer's Disease and Infectious Causes
With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimer's disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimer's disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimer's patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimer's disease. Sources of infection in Alzheimer's disease vary from childhood infections t...
Mars im hohen Haus
Der Dienst als Offizier stellte in der Sattelzeit um 1800 eine zentrale Arena im vielzitierten Ringen des Adels um das Obenbleiben dar. Diesem Teil der adligen Lebenswelten hat sich die neuere Adelsforschung lange nicht angenommen. Florian Schönfuß nimmt auf der Grundlage bisher unzugänglichen Quellenmaterials aus den Privatarchiven des rheinischen Adels eine regionale Adelsgesellschaft in den Blick, die aufgrund der langen französischen Herrschaft am Rhein von den tiefgreifenden Umbrüchen im Kielwasser der Französischen Revolution in besonderer Weise tangiert war. Mithilfe eines generationenübergreifenden Ansatzes erläutert er die steigende Bedeutung von Offizierslaufbahnen bei der Akquise von klientelaren Bindungen, Einkünften, sozialem Prestige und politischem Einfluss. Erstmals wird die adlige Militärlaufbahn aus der mikrogeschichtlich-innerfamiliären Perspektive heraus als wichtiges Instrument einer patriarchalisch verfassten Familienpolitik greifbar, das der rheinische Adel auf virtuose Weise nutzte, um auf grundlegend veränderte gesellschaftlich-politische Rahmenbedingungen zu reagieren.
The Microbiome and the Brain
Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And, until recently, these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health, functionality, and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain, through the contributions of some of the most forward thinking researchers and clinicians in the field, comprehensively reveals the leading edge of our understanding of the fundamental role of gut ...
Tax Court Memorandum Decisions
Contains the full texts of all Tax Court decisions entered from Oct. 24, 1942 to date, with case table and topical index.
Journal of the House of Representatives of the United States
Reprint of the original, first published in 1867.
George Tooker
This Reprint Contains Over 150 Paintings of George Tooker. The color reproductions capture the luminous quality of the artist's work in egg tempera, and his meticulous painting technique is described in detail through an intimate look into Tooker's studio. For more than forty-five years Tooker has painted haunting psychological landscapes that explore the human condition of modern society, all characterized by mystery, magic, ambiguity, symbolism, classical form, and masterful technique. The absorbing images both enchant and repel us in their forceful depiction of the complexities of our age while clearly demonstrating the artist's love of composition and human form.
George Tooker
For more than 60 years, George Tooker (1920-2011) created luminous and often enigmatic paintings, addressing issues from alienation and the dehumanizing aspects of contemporary society to personal meditations on the human condition. From the Cold War urban purgatories and bureaucratic paranoia of his early paintings to his later warm, glowing images of lovers embracing in fields or found in windows, Tooker's spiritual vision ultimately stands as a quest for the endless possibilities of intimacy, compassion and tolerance. Widespread public recognition first came to Tooker through his best-known painting, "Subway" (1950), a definitive image of anxiety and dread. His more utopian themes of peace, brotherhood and reconciliation would find expression in such works as "Embrace of Peace II" (1988). Published in conjunction with DC Moore Gallery's memorial exhibition, George Tooker: Reality Recurs as a Dream features paintings from every period of Tooker's long career.
