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Hypoxia and Cancer
The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metab...
University in the fight against mafias: Research, teaching and training
The commitment of Italian universities to education in the field of legality and to research on the subject of mafias is the main focus of this investigation edited by Stefano D’Alfonso and Gaetano Manfredi. For the first time, data is shown about the overall framework of teaching and research activities dedicated to this topic, with twenty-nine scholars from different academic disciplines and several universities who come together to reflect on the current situation and on the commitment of universities in the fight against mafias, highlighting both strengths and weaknesses of the system. The reflections illustrated here bring to light the dynamic nature of the local and cultural context ...
Women of the Mafia
Women of the Mafia dives into the Neapolitan criminal underworld of the Camorra as seen and lived by the women who inhabit it. It tells their life stories and unpacks the gender dynamics by examining their participation as active agents in the organization as leaders, managers, foot soldiers, and enablers. Felia Allum shows that these women are true partners in crime. The author offers an innovative interdisciplinary analysis that demystifies the notion that the Camorra is a sexist, male-centric organization. She links her analysis of Camorra culture within the wider Neapolitan context to show how mothers and women act and are treated in the private sphere of the household and how the family helps explain the power women have found in the Neapolitan Camorra. It is civil society and law enforcement agencies that continue to see the Camorra using traditional gender assumptions which render women irrelevant and lacking independent agency in the criminal underworld. In Women of the Mafia, Allum debunks these assumptions by revealing the power and influence of women in the Camorra.
Guidance Molecules in Cancer and Tumor Angiogenesis
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Guidance molecules in Cancer and cancer angiogenesis". With outstanding and original reviews, this volume covers topics such as Guidance for life, death and neoplasia by netrin receptors, Semaphorin signals tweaking the tumor microenvironment, NOTCH Activation in Human Malignancy, and Essential roles of EphrinB in endothelial cell function and angiogenesis.
Oxygen Biology and Hypoxia
For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of oxygen biology and hypoxia.
The Tumor Microenvironment
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and...
Targeted Therapies in Oncology
Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere inter
