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Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the third of three volumes on recent developments in ...
Written by one of the world's foremost authorities on the subject, this is the most comprehensive and in-depth treatment available to environmental engineers and scientists for the remediation of groundwater, one of the earth's most precious resources. Groundwater is one of the Earth's most precious resources. We use it for drinking, bathing, and many other purposes. Without clean water, humans would cease to exist. Unfortunately, because of ignorance or lack of caring, groundwater is often contaminated through industrialization, construction or any number of other ways. It is the job of the environmental engineer to remediate the contaminated groundwater and make what has been tainted safe ...
i-SMOOTH ANALYSIS A totally new direction in mathematics, this revolutionary new study introduces a new class of invariant derivatives of functions and establishes relations with other derivatives, such as the Sobolev generalized derivative and the generalized derivative of the distribution theory. i-smooth analysis is the branch of functional analysis that considers the theory and applications of the invariant derivatives of functions and functionals. The important direction of i-smooth analysis is the investigation of the relation of invariant derivatives with the Sobolev generalized derivative and the generalized derivative of distribution theory. Until now, i-smooth analysis has been dev...
The search for alternative sources of energy to offset diminishing resources of easy and cost-effective fossil fuels has become a global initiative, and fuel generated from biomass is a leading competitor in this arena. Large-scale introduction of biofuels into the energy mix could contribute to environmentally and economicaly sustainable development on a global scale. The processes and methodologies presented in this volume will offer a cutting-edge and comprehensive approach to the production of biofuels, for engineers, researchers, and students.
Comprehensive and practical, Pavement Asset Management provides an essential resource for educators, students and those in public agencies and consultancies who are directly responsible for managing road and airport pavements. The book is comprehensive in the integration of activities that go into having safe and cost-effective pavements using the best technologies and management processes available. This is accomplished in seven major parts, and 42 component chapters, ranging from the evolution of pavement management to date requirements to determining needs and priority programming of rehabilitation and maintenance, followed by structural design and economic analysis, implementation of pavement management systems, basic features of working systems and finally by a part on looking ahead. The most current methodologies and practical applications of managing pavements are described in this one-of-a-kind book. Real world up-to-date examples are provided, as well as an extensive list of references for each part.
This groundbreaking volume covers the significant advantages of wave technologies in the development of innovative machine building where high technologies with appreciable economic effect are applied. These technologies cover many industries, including the oil-and-gas industry, refining and other chemical processing, petrochemical industry, production of new materials, composite and nano-composites including, construction equipment, environmental protection, pharmacology, power generation, and many others. The technological problem of grinding, fine-scale grinding and activation of solid particles (dry blends) is disclosed. This task is common for the production of new materials across thes...
Hydraulic fracturing, commonly referred to as “fracking,” is a technique used by the oil and gas industry to mine hydrocarbons trapped deep beneath the Earth’s surface. The principles underlying the technology are not new. Fracking was first applied at the commercial level in the United States as early as 1947, and over the decades it has been applied in various countries including Canada, the UK, and Russia. The author worked with engineering teams as early as the mid-1970s in evaluating ways to improve oil recovery from this practice. By and large fracking was not an economically competitive process and had limited applications until the early 2000s. Several factors altered the impor...
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
The main aim of the book is to present new constructive methods of delay differential equation (DDE) theory and to give readers practical tools for analysis, control design and simulating of linear systems with delays. Referred to as “systems with delays” in this volume, this class of differential equations is also called delay differential equations (DDE), time-delay systems, hereditary systems, and functional differential equations. Delay differential equations are widely used for describing and modeling various processes and systems in different applied problems At present there are effective control and numerical methods and corresponding software for analysis and simulating differen...
Introducing a new practical approach within the field of applied mechanics developed to solve beam strength and bending problems using classical beam theory and beam modeling, this outstanding new volume offers the engineer, scientist, or student a revolutionary new approach to subsea pipeline design. Integrating use of the Mathematica program into these models and designs, the engineer can utilize this unique approach to build stronger, more efficient and less costly subsea pipelines, a very important phase of the world's energy infrastructure. Significant advances have been achieved in implementation of the applied beam theory in various engineering design technologies over the last few de...