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Hemochromatosis
Once considered a rare condition, hemochromatosis is now acknowledged as one of the commonest inherited disorders, affecting one in two hundred people of Western Caucasian descent and in the U.S. alone, over one million people. This is the most comprehensive clinical reference yet on hemochromatosis. The international team of 94 authors from twelve countries includes specialists in internal medicine, hematology, hepatology, genetics, biochemistry, and molecular biology. In 57 in-depth chapters they cover all aspects of pathophysiology, epidemiology, diagnosis and treatment. The text thoroughly explains the latest developments in the genetics of the disorder, including sections on screening, diagnostic techniques, and clinical complications. In addition, chapters consider social and ethical issues. With over 200 illustrations--including 40 color plates--this is today's definitive resource for all clinicians involved in the management of hemochromatosis, and for scientists interested in iron metabolism and iron overload.
Nuno Sousa Vieira
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Fernando Lopes-Graça e Eugénio de Andrade - O Diálogo entre a Música e a Poesia
Os nomes de Fernando Lopes-Graça e Eugénio de Andrade figuram entre as mais ilustres referências da vida cultural portuguesa do século XX. O primeiro, compositor de primeira ordem. O segundo, um dos poetas mais difundidos da nossa literatura moderna. Ambos, grandes homens de cultura e que primaram pela interligação fundamental entre a palavra e a música, patente nos três ciclos de canções sobre poesia de Eugénio de Andrade, que Lopes-Graça compôs, bem como num diálogo muito mais vasto que a correspondência entre ambos (entre 1956 e 1993) pode testemunhar. Através deste diálogo artístico assistimos a um constante contraponto, uma conversa "postal", numa dinâmica de "pergunta" e "resposta", que nos dá muito da história e dos meandros da vida cultural em Portugal na segunda metade do século XX, mas, acima de tudo, traz a lume elementos eminentemente biográficos pela pena dos próprios artistas.
Iron Physiology and Pathophysiology in Humans
Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and ot...
Convicts and Orphans
This book examines how the early modern Portuguese state used convicts and orphans to populate its global empire. In addition, it addresses the issue of gender in the state's use of two distinct groups of single women as colonizers, orphan girls and reformed prostitutes, each given state-awarded dowries if they agreed to relocate overseas.
The Importance Of Iron In Pathophysiologic Conditions
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protei...
Iron as Therapeutic Targets in Human Diseases
Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegene...
Hepatology
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