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Biosystems Engineering II
Biosystems Engineering I explores all aspects of biotechnology, which blends aspects of chemistry, biochemistry, microbiology, genetics, chemical engineering and computer sciences. Topics include the systems biology of industrial microorganisms, modeling languages for biochemical network simulation, and more.
Metabolic Network Analysis of the Cell Factory Aspergillus niger
In the present work, a systems biology approach is presented, which enables the prediction of potential genetic targets and optimal pathways for protein production within a metabolic network, and thus, makes an important contribution to the rational strain optimization of micro-organisms. For this, elementary flux modes analysis was carried out using a metabolic model of Aspergillus niger, which was condensed from the genome based metabolic model. Hereby, a new approach was developed for the design of cell factories by the analysis of metabolic flux correlations between metabolic enzymes. This allowed the in silico prediction of deletion and amplification targets and thus provides an importa...
Official Gazette
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Chemnitzer Adreßbuch
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