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This book reviews the state of the art presented by highly competent authors. The first two chapters are dedicated to clinical aspects of early diagnosis of important tumor types such as cervical cancer, breast cancer, cancer of the prostate and transitional cell carcinoma, skin cancer and melanoma, cancer of the oral cavity, esophagus, stomach and colon, and hematological malignancies. In the following chapters the value of the different methodological approaches to early detection of cacner are reviewed: tomor markers, imaging procedures, histo- and cytopathology, cytogenetic and molecular genetic methods. The book is of interest to all physicians, to researchers who accept the challenge to improve early detectin of cancer, and to governmental or charity institutions designing and supporting screening programs for early detectionof cancer.
"Metastatic Bone Disease: Fundamental and Clinical Aspects" is an expanded version of a workshop on bone metastases which was held in Heidelberg, Germany, in April 1993. Bone metastases very often develop from malignant tumors and lead to complications which considerably diminish the quality of life of the patient. Bone pain, pathological fractures, and hypercalcemic syndrome should be recognized and treated ear- ly, so as to prevent any further morbidity and immobilizati- on. Antiosteolytic substances such as biophosphonate can supplement the established palliative and supportive thera- pies. Highly qualified basic researchers and clinicians in pathophysiology, diagnosis, and treatment of metastatic bone disease have contributed to this book, providing a good overview ofpresent knowledge and research. The book will be of interest not only to specialists, but also to any physi- cian interested in oncology.
First multi-year cumulation covers six years: 1965-70.
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