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Complex Systems
The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. At the Conference on Complex Systems, participants were divided into twelve interdisciplinary working groups. The groups spent nine hours over two days exploring diverse challenges at the interface of science, engineering, and medicine. The groups included researchers from science, engineering, and medicine, as well as representatives from private and public funding agencies, universities, businesses, journals, and the science media. The groups needed to address the challenge of communicating and working together from a diversity of expertise and perspectives as they attempted to solve complicated, interdisciplinary problems in a relatively short time. The summaries contained in this volume describe the problem and outline the approach taken, including what research needs to be done to understand the fundamental science behind the challenge, the proposed plan for engineering the application, the reasoning that went into it and the benefits to society of the problem solution.
Systems Biology
The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Syste...
Complex Systems Science in Biomedicine
Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, ...
Chronic Lymphocytic Leukemia
Written by authors from the world's most prominent cancer centers, Chronic Lymphocytic Leukemia supplies a comprehensive, up-to-date picture of CLL and how to better treat patients inflicted with the disease.New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care.
Molecular Hematology
Unique text providing a core knowledge base for those withlittle exposure to molecular biological methods Molecular Haematology provides essential reading for those withminimal exposure to, or understanding of, molecular biologicaltechniques. There is an extensive glossary and each chapter iswritten with the non-specialist in mind. Molecular Haematology is ideal for: Trainees and residents in hematology Hematologists in practice Why Buy This Book? Unique text providing a core knowledge base for those withlittle exposure to molecular biological methods Focuses on the clinical relevance of molecular biology inhaematology Complete revision of text and ten new chapters to cover allgroundbreaking developments in the field Each chapter summarizes the impact made by molecular researchon understanding the pathogenesis of a variety of blooddisorders International team of contributors recruited from topspecialist units around the world
Nanopores
Nanopores are nanometer scale holes formed naturally by proteins or cells, and can be used for a variety of applications, including sequencing DNA and detecting anthrax. They can be integrated into artificially constructed encapsulated cells of silicon wafers while allowing small molecules like oxygen, glucose and insulin to pass, while keeping out large system molecules. "Nanopores: Sensing and Fundamental Biological Interactions" examines the emerging research directions surrounding nanopores such as genome sequencing and early disease detection using biomarker identification. Covering the applications of nanopores in genetics, proteomics, drug discovery, early disease detection and detection of emerging environmental threats, it is a must-have book for biomedicalengineers and research scientists.
The Lymphoid Neoplasms 3ed
This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengt
Reverse Engineering Biological Networks
"This volume is the result of a workshop entitled Dialogue on Reverse Engineering Assessment and Methods (DREAM) held on September 7-8, 2006, at Wave Hill, New York"--P [vii].
Statistical Implicative Analysis
Statistical implicative analysis is a data analysis method created by Régis Gras almost thirty years ago which has a significant impact on a variety of areas ranging from pedagogical and psychological research to data mining. Statistical implicative analysis (SIA) provides a framework for evaluating the strength of implications; such implications are formed through common knowledge acquisition techniques in any learning process, human or artificial. This new concept has developed into a unifying methodology, and has generated a powerful convergence of thought between mathematicians, statisticians, psychologists, specialists in pedagogy and last, but not least, computer scientists specialized in data mining. This volume collects significant research contributions of several rather distinct disciplines that benefit from SIA. Contributions range from psychological and pedagogical research, bioinformatics, knowledge management, and data mining.
