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Neurogenetics in Neurology: From Molecular Neuroscience to Precision Medicine
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Ion Channel Diseases
Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.
Rapid-Eye-Movement Sleep Behavior Disorder
This book describes a sleep disorder belonging to the category of parasomnias (i.e. the sleep behavioral and experiential disorders) characterized by abnormal vocal and motor behaviors in the context of vivid dreams and loss of the customary muscle atonia during the stage of sleep called REM sleep. REM-atonia - one of the defining features of REM sleep, along with rapid-eye-movements and a highly activated brain state - serves a protective function, preventing the dreamer from acting-out dreams and becoming injured. REM sleep behavior disorder (RBD) was first described in 1986 by Schenck and colleagues; since then the understanding of the condition has increased exponentially, also pointing ...
Satellite Boy
Spanning the underworld haunts of Montreal to Havana and Miami in the early days of the Cold War, Satellite Boy reveals the unlikely connection between an audacious bank heist and the “other Space Race” that gave birth to the modern communication age On April 6, 1965, Georges Lemay was relaxing on his yacht in a south Florida marina following one of the largest and most daring bank heists in Canadian history. For four years, the roguishly handsome criminal mastermind hid in plain sight, eluding capture and the combined efforts of the FBI, Interpol, and the Royal Canadian Mounted Police. His future appeared secure. What Lemay didn’t know was that less than two hundred miles away at Cape...
AKC Gazette
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Syringomyelia
Syringomelia is a relatively rare clinical entity in which fluid-filled cavities develop within the spinal cord. Although modern imaging technologies usually permit an accurate diagnosis at an early stage, syringomyelia remains an enigmatic condition. This reference monograph provides an up-to-date account of the present state of understanding of syringomyelia and related disorders. The editors aim to document the best clinical practice in diagnosis and treatment and to provide clear guidance on how to reduce the incidence of severe outcomes. New challenges are addressed, including the appropriate management of the increasing number of apparently idiopathic syrinx cavities that are detected. In addition, controversies in current practice and directions for future research are fully discussed. Syringomelia will be an invaluable source of information for experts in the field, specialists in various related disciplines and other interested health care professionals.
Inherited Susceptibility to Cancer
Many cancers, both common and rare, are known to have a hereditary predisposition and advances in genetics have clarified the risks and in some cases the mechanisms of cancer developing in an individual. First published in 1998, this important contribution to the literature of cancer genetics covers all the key issues, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. It is divided into two parts. The first deals with ethical, legal and social issues. The second systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. This authoritative volume will be of interest to oncologists, physicians and surgeons in other specialities and to health professionals in the areas of primary care, counselling and cancer risk assessment.
Public Purpose
In the clear, vigorous, and candid prose that is his trade mark, Kent recalls his role in the crises and triumphs of the Pearson government: the "Sixty Days of Decision," Walter Gordon's first budget, the flag debate, Medicare, the elventh-hour negotiations with Jean Lesage that averted a constitutional rupture over the Canada Pension Plan, and, after 1965, Pearson's increasing exhaustion and disenchantment. From the Pearson years, the book moves to the Trudeau impact on Ottawa, the regional development program, and the disagreement on economic policy that led Kent to leave Ottawa in 1971.
Canada and the End of Empire
Sir John Seeley once wrote that the British Empire was acquired in “a fit of absence of mind.” Whatever the truth of this comment, it is certainly arguable that the Empire was dismantled in such a fit. This collection deals with a neglected subject in post-Confederation Canadian history – the implications to Canada and Canadians of British decolonization and the end of empire. Canada and the End of Empire looks at Canadian diplomatic relations with the United Kingdom and the United States, the Suez crisis, the changing economic relationship with Great Britain in the 1950s and 1960s, the role of educational and cultural institutions in maintaining the British connection, the royal tour ...
