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This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.
Many cancers, both common and rare, are known to have a hereditary predisposition and advances in genetics have clarified the risks and in some cases the mechanisms of cancer developing in an individual. First published in 1998, this important contribution to the literature of cancer genetics covers all the key issues, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. It is divided into two parts. The first deals with ethical, legal and social issues. The second systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. This authoritative volume will be of interest to oncologists, physicians and surgeons in other specialities and to health professionals in the areas of primary care, counselling and cancer risk assessment.
Over the last 20 years it has become increasingly apparent that the occurrence of many cancers can have an inherited basis. This book examines the principles underlying genetic predisposition to cancer and will be relevant to practising oncologists, geneticists and other professionals interested in this rapidly expanding field. Coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the identification and characterisation of predisposition genes, to a consideration of heritable cancer syndromes, and encompasses both rare and common cancers. The text also features a discus...
Medical genetics.
With genetic technologies advancing rapidly, Aisling de Paor examines the urgent need for an EU-level framework to regulate genetic information.
Screening for cancer is an important focus of cancer control. Yet screening, as it involves administering a test to large segments of the population deemed to be at risk for the disease of interest, is potentially a major consumer of scarce health care resources. In addition, the benefits sought from cancer screening, particularly reduction in mortality from the disease, are not always realized, either for biological or organizational reasons. Thus, the paradigm that `early detection must always be beneficial', taught to health care professionals, and publicized widely through the media to the public, has been challenged in the last two decades for a number of cancer sites. It is the purpose of Advances in Cancer Screening to determine the extent to which the requirements for the introduction of population-based screening programs have been met, as a result of extensive research on screening during the last two decades, with a major concentration on findings from the recent decade.