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The Nidoviruses
This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases. The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting. This represents the only comprehensive book to cover this field in the last five years.
Clinical Virology
Informs scientists and health care professionals about all the medically relevant aspects of this rapidly evolving field. • Covers novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention. • Addresses infections and syndromes related to particular organ systems, as well as the fundamentals of modern medical virology. • Includes crucial information on immune responses and vaccinology, diagnostics, antivirals, and the nascent field of gene therapy. • Provides agent-specific chapters that detail the virology, epidemiology, pathogenesis, clinical manifestations, and prevention and treatment of important viral pathogens.
Cyberbiosecurity
Cyberbiosecurity applies cybersecurity research to the field of biology, and, to a lesser degree, applies biological principles to the field of cybersecurity. As biologists increasingly research, collaborate, and conduct research online, cyberbiosecurity has become crucial to protect against cyber threats. This book provides an overview of cyberbiosecurity through the lens of researchers in academia, industry professionals, and government, in both biology and cybersecurity fields. The book highlights emerging technologies, and identifies emerging threats connected with these technologies, while also providing a discussion of the legal implications involved. This book takes on a multidisciplinary approach, and appeals to both professionals and researchers in the synthetic biology, bioinformatics, and cybersecurity fields.
Proteases and Their Inhibitors in Cancer Metastasis
In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.
Antibiotic Resistance
Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.
The Human Oncogenic Viruses
The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of the cancer's biology, which if understood at the molecular level should identify key diagnostic and therapeutic manipulation points. Advances in recombinant gene technology have provided significant understanding of the mechanisms of action of oncogenic viruses, as well as of cancer-associated genomic sequences (onco genes). This text will explore the known molecular genetic, biolog ical, and clinical knowledge of selected human neoplasms that demonstrate association with suspected oncogenic viru...
Antiviral Discovery for Highly Pathogenic Emerging Viruses
Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents.
AIDS-Associated Viral Oncogenesis
One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.
A Strategic Vision for Biological Threat Reduction
The National Academies of Sciences, Engineering, and Medicine was asked to articulate a 5-year strategic vision for international health security programs and provide findings and recommendations on how to optimize the impact of the Department of Defense (DOD) Biological Threat Reduction Program (BTRP) in fulfilling its biosafety and biosecurity mission. Because BTRP is just one of several U.S. government programs conducting international health security engagement, both the strategic vision and the success of the program rely on coordinating actions with the U.S. government as a whole and with its international partners. This report provides several recommendations for optimizing BTRP success in its current mission and the wider-looking strategic vision it proposes.
Vector-Borne Diseases
Vector-borne infectious diseases, such as malaria, dengue fever, yellow fever, and plague, cause a significant fraction of the global infectious disease burden; indeed, nearly half of the world's population is infected with at least one type of vector-borne pathogen (CIESIN, 2007; WHO, 2004a). Vector-borne plant and animal diseases, including several newly recognized pathogens, reduce agricultural productivity and disrupt ecosystems throughout the world. These diseases profoundly restrict socioeconomic status and development in countries with the highest rates of infection, many of which are located in the tropics and subtropics. Although this workshop summary provides an account of the indi...
