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Hormone Resistance and Hypersensitivity
Over recent years, impressive advances in genetic/epigenetic technology have greatly improved the understanding of the pathogenesis of pediatric endocrine diseases due to hormone resistance and hypersensitivity.This book presents reviews of thyroid hormone and thyroid hormone receptor resistance, and genetics and epigenetics of parathyroid hormone resistance. Abnormalities of the pituitary-gonadal axis affecting puberty as well as androgen receptor are covered. Novel insights into the diseases affecting ACTH, glucocorticoid and aldosterone receptors are discussed. Further chapters address new aspects of the physiology of the GH and IGF-1 axis as well as the diseases related to GH-IGF-1 receptor and post-receptor signaling defects. A key chapter on metabolic insights into insulin resistance is also included. Covering clinical and genetic aspects of hormone resistance and hypersensitivity, this book will be a useful tool in the hands of scientists, physicians and other healthcare professionals who wish to be up to date with novel research findings in this area.
Resilience in Aging
The many significant technological and medical advances of the 21st century cannot overcome the escalating risk posed to older adults by such stressors as pain, weakness, fatigue, depression, anxiety, memory and other cognitive deficits, hearing loss, visual impairment, isolation, marginalization, and physical and mental illness. In order to overcome these and other challenges, and to maintain as high a quality of life as possible, older adults and the professionals who treat them need to promote and develop the capacity for resilience, which is innate in all of us to some degree. The purpose of this book is to provide the current scientific theory, clinical guidelines, and real-world interv...
The Hypothalamus-Pituitary-Adrenal Axis
The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later
Stress - From Molecules to Behavior
This title comprehensively covers the molecular basis of stress responses of the nervous system, providing a unique and fundamental insight into the molecular, physiological and behavioral basis of the stress response of a whole organism. Edited by leading experts in the field and summarizing the latest research advances in this area, this ready reference is an invaluable resource for clinicians dealing with stress-related disorders, biomedical researchers working in the field as well as for pharmacology and biotech companies.
Endocrine Hypertension
The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure. The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients. Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension. In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of many conditio...
Stress and Health
Acute stressful experiences or high levels of chronic stress are risk factors for mental and physical disorders. Insights into the effects of posttraumatic stress disorder and other stress-related disorders experienced by war veterans, refugees, and immigrants are presented. This volume also presents examinations of the pathological effects of stress that may disrupt the normal relationships between individuals and their families. The health of individuals and their children may be enhanced by interventions to help them manage the effects of stressful life experiences and environments. Innovative and effective interventions are examined and their applications are recommended.
Clinical Pharmacology of Anti-Epileptic Drugs
"He who is faithfully analysing ... epi lepsy is doing far more than studying epilepsy" Hughlings Jackson Modifying this well-known statement by Jackson, one could say today: "He who is faithfully analysing anti-epileptic drugs is doing far more than studying anti-epileptic drugs". For these drugs not only serve to prevent epileptic fits and thus advance the treatment of epilepsy, they are also effective in the treatment of cardiac arrhythmias and trigeminal neuralgia. Furthermore, clinical pharmacologists consider anti-epi leptic drugs as model drugs in pharmacokinetics and pharmocodynamics, since reliable methods are available for their determination and their effects and side effects can ...
Fat: the Secret Organ
The International Bestseller, as featured in The Times Fat is a vital yet hugely under-rated organ. Fat has become a dirty word, but we know so little about how it really works. In Fat, expert doctors and obesity researchers Dr Mariëtte Boon and Professor Liesbeth van Rossum present the ground-breaking research which explodes many of the myths and prejudices surrounding body fat and will make us completely rethink our relationship with it. Making use of the cutting-edge research in this specialist field, this fascinating and entertaining book will explain how fat generates important hormones, communicates with our brains and is, indeed, essential for staying alive. Informative yet accessible, Fat: The Secret Organ is important reading, not only for people who have struggled with their weight, but for everybody who is serious about their health.
