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Weight Management
The physiological or pathological variations in the amount or mass of each component of body weight can lead to an increase or a decrease in total body weight, with a potential risk of increased morbidity and mortality. This book presents an overview of current knowledge about different types of body weight changes, with a special emphasis on obesity.
Weight Management
Weight management is a multi- and cross-disciplinary challenge. This book covers many etiological and diagnostic aspects of weight-related disorders and their treatment. This book explains how body weight influences and is influenced by the brain, hormones and immune system, diet, physical activity, posture and gait, and the social environment. This book also elucidates the health consequences of significantly low or pathologically increased body weight. Furthermore, ideas on how to influence and manage body weight including anti-obesity medical devices, diet counselling, artificial sweeteners, prebiotics and probiotics, proanthocyanidins, bariatric surgery, microbiota transplantation, warming, physical exercise, music and psychological therapy are discussed.
Mechanisms and Management of Senescence
Senescence represents a complex universal phenomenon that can be impacted by several factors. It is emerging as a therapeutic target for several diseases. This book presents an overview of the current mechanisms and management of senescence in humans. It also provides comparative data on senescence in animals and plants.
Environmental Issues and Sustainable Development
In recent years, attention to climate change and its associated impacts on economic and social development has increased significantly. Extreme weather conditions worldwide are threatening the survival of sensitive species and habitats. The situation is so dire that governments, academia, and non-governmental organizations across the globe are actively working to meet the United Nations Sustainable Development Goals. This book enhances understanding of environmental changes and the relative response to the socio-economic challenges of development. It provides a comprehensive overview of the impact of environmental change on natural resources and the climate, as well as discusses waste management and sustainable solutions.
Update in Geriatrics
Geriatric is a topic of great interest in medicine and among the general public. Population aging is an inevitable and irreversible demographic reality that is associated with welcome improvements in health care. The increase in life expectancy has led the very old to become the fastest-growing segment. The geriatric population experiences significant alterations of numerous organ systems as a result of the aging process. Normally, functional reserve and organ functions are declined in geriatric patients. The care of geriatric patients can be complex and will be a growing task. A balance between physiological and psychological alterations is required in these patients. Geriatric patients also have several co-morbidities including hypertension, cardiac disease, diabetes, cerebrovascular disease, and renal dysfunction.
Advances in Hepatology
This book discusses clinical advances in hepatology, with a focus on metabolic diseases and chronic hepatitis C. The development of direct-acting antiviral (DAA) agents for the treatment of hepatitis C virus (HCV) infection in 2010 has completely transformed the management of this disease. This transformative nature of DAA therapy underpins the goal of the World Health Organization (WHO) to eliminate HCV infection as a public health threat by 2030. The advantages of using these therapies include high efficacy (sustained virological response rate >95%) with minimal side effects, good tolerability, easy drug administration (once-daily oral dosing) and short duration of treatment (8-12 weeks). The commercialization of second-generation DAA agents due to their high effectiveness, few side-effects and pangenotypic action. This transformative nature of DAA therapy underpins the goal of the WHO to eliminate HCV infection as a public health threat by 2030.
Graves' Disease
Graves’ disease is caused by autoantibodies to the thyroid gland that mimic thyroid-stimulating hormone, causing the gland to overproduce thyroid hormone. This speeds the metabolism of the patient and can lead to dangerous conditions including atrial fibrillation and heart failure. Mainstays of treatment have included antithyroid medication, surgical removal of the thyroid gland, and more recently, radiofrequency ablation of the thyroid gland. Advancements in diagnostic testing have enhanced our understanding of the natural course of the disease, creating additional therapeutic options. Enhanced understanding of the autoimmunity behind the disorder may lead to therapeutic options that address the underlying autoimmunity. This book provides a comprehensive review of these enhancements and how they have resulted in changes in common clinical practice.
COVID-19 and Diabetes: Current Findings and Future Perspectives
Since the end of 2019, Coronavirus disease 2019 (COVID-19), which caused more than 6 million deaths worldwide, immediately gained attention as a major public health issue. The clinical spectrum of COVID-19 encompasses a wide range of conditions, from a minor upper respiratory tract infection to severe interstitial pneumonia with respiratory and even multi-organ failure and a high in-hospital mortality. This unpredictability encouraged the development of tailored vaccination tactics to control the viral propagation and slow the progression of the disease. During the pandemic, a vast amount of clinical and laboratory data was gathered, allowing researchers to learn more about the progression of the disease as well as the efficacy and safety of the anti-SARS-Cov-2 vaccine.
Metal Nanocomposites in Nanotherapeutics for Oxidative Stress-Induced Metabolic Disorders
This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's di...
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