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Environmental Endocrine Disruptors
Addresses many aspects of endocrine disruption by environmental encountered toxic substances. Initial chapters provide essential background information whilst later chapters address specific aspects of endocrine disrupting contaminants (EDC)
Intervention with Hyperactive Children
Hyperactivity has historically been a major concern of parents and teachers. Over the years, the term has come to mean many things to different persons. For some, the term is synonymous with "brain damage," and the prescribed course of treatment is medical. For others, the term is a catch all, covering almost any behaviors that are found to be obtrusive or disrup tive by the child's caretakers. In recent years, there has been a great outcry by some over the use and abuse of the term as a justification for controlling the child. Others have expressed great concern over the excessive, inappro priate, or poorly monitored use of drug therapy with regard to hyperactivity. The current interest in ...
Manual of Immunological Methods
The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to enhance the successful application of this science. It emphasizes the need for continuously improving the quality of experiments performed and maintaining consistency in the results obtained. The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work in the spirit of the Good Laboratory Practices. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduate students and practicing researchers in the areas of immunology and immunotoxicology will appreciate the Manual of Immunological Methods as a guide to standard operating procedures in the laboratory.
Reproductive and Developmental Toxicity of Metals
The Permanent Commission and International Association on Occupational Health (PCIAOH) established in 1969 a Subcommittee on the Toxicology of Metals under the chairmanship of Lars Friberg. This committee, which later was named the Scientific Committee on the Toxicology of Metals, has organized a number of previous meetings that have led to publications in three major areas of metal toxicology: a preliminary meeting in Slanchev Bryag, Bulgaria in- 1971, followed by a meeting in 1972 in Buenos Aires, Argentina which produced two reports (Dukes and Friberg, 1971; Task Group on Metal Accumulation, 1973), that discussed the metabolism of metals with special reference to absorption, excretion and...
Introduction to Neurobehavioral Toxicology
Introduction to Neurobehavioral Toxicology: Food and Environment examines the effects of chemicals on the central and peripheral nervous system and the subsequent changes in behavior, with a focus on the toxicity of food components and behavioral effects of environmental toxicants. Topics addressed include acute and chronic effects; reversible and
Immune Interferon
Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Interferon-gamma is a natural immune booster which has been synthesized and widely used in clinical cases ranging from infectious diseases to cancer, as well as various metabolic disorders. Having developed their own brand of interferon-gamma, the authors are well known in the scientific community. In Immune Interferon: Properties and Clinical Applications, they bring together the extensive findings from twenty years of research since the discovery of the drug. Focusing on the drug itself, and not particular brands, the book presents data on the properties of interferon-gamma, experimental data on its effects, and its clinical applications.
Cell Death
Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e
