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Outcomes in Clinical Trials
The traditional end-points for clinical studies of lung diseases were based on functional parameters. Their value as surrogate markers for disease activity and progression has been increasingly questioned by scientists, carers, regulatory agencies and funding bodies. Novel tools and methods with regard to biomarkers and patient-reported outcomes have made these parameters emerge from their status as interesting secondary end-points and become potential primary outcomes for clinical trials. Nevertheless, their relevance and validity still needs to be proven. This issue of the European Respiratory Monograph describes the current status regarding end-points in all relevant areas of pulmonary medicine.
Textbook of Pulmonary Rehabilitation
This book provides up-to-date knowledge on all aspects of the multidisciplinary approach to pulmonary rehabilitation that is essential in order to achieve optimal results. It will be an ideal resource especially for pulmonologists in training, but will also be of value for physiotherapists, other health care professionals, and technicians. Detailed information is presented on the diverse program components in pulmonary rehabilitation, with clear explanation of the roles of the nutritionist, psychologist, occupational therapist, respiratory nurse, and physical activity coach. Guidance is provided on identification of candidates for pulmonary rehabilitation and on all aspects of assessment, including exercise capacity, muscle function, and physical activity. Patient-centered, economic, and other outcomes are examined, with separate discussion of combined outcome assessment. Furthermore, due consideration is given to organizational aspects of pulmonary rehabilitation and to rehabilitation in specific scenarios, e.g., thoracic oncology and surgery, transplantation, and the ICU. The authors are internationally recognized experts selected for their expertise in the topics they discuss.
Innovative 3D models for Understanding Mechanisms underlying Lung Diseases: Powerful Tools for Translational Research
The mechanisms underlying acute and chronic lung diseases are complex, reflecting the interplay between multiple cell types, their microenvironment and exogenous challenges. While traditional in vitro cell culture approaches have been instrumental in advancing our knowledge of cellular signalling and function, they typically lack the cell-cell and cell-matrix interactions that define the niche in which lung cell and tissue functions emerge. Implementing in vivo and ex vivo three-dimensional (3D) models more realistically mimicking the in vivo cell-extracellular matrix (ECM) crosstalk should facilitate a considerable leap towards better understanding lung diseases and thus in investigating ne...
Pulmonary Rehabilitation
Pulmonary rehabilitation programmes are a fundamental part of the clinical management of patients with chronic respiratory diseases. This comprehensive reference book places pulmonary rehabilitation within the wider framework of respiratory disease. Now in six parts, it includes new sections on the development of PR as a discipline, global perspectives on quality control, new chapters on early PR post exacerbation and personalized rehabilitation, innovative approaches to exercise, PR in interstitial lung disease and lung transplantation, and the latest research into the application of music, dance and yoga. Key Features Global contributions compare practice around the world where differences...
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ALLMANNA CIRKULAR.
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COPD
Die COPD ist zur Volkskrankheit geworden. Weltweit ist sie die häufigste zum Tode führende Lungenerkrankung. Die persistierende und fortschreitende Atemwegsobstruktion ist vermeidbar, mit Tabakkonsum als wesentlichem behandelbaren Risikofaktor. In den letzten Jahren ist es dank vieler experimenteller Untersuchungen und Studien gelungen, das Verständnis für die Erkrankung sowie die Therapie und Versorgung der Patienten signifikant zu verbessern.
Guide to the Euphonium Repertoire
Guide to the Euphonium Repertoire is the most definitive publication on the status of the euphonium in the history of this often misunderstood and frequently under-appreciated instrument. This volume documents the rich history, the wealth of repertoire, and the incredible discography of the euphonium. Music educators, composers/arrangers, instrument historians, performers on other instruments, and students of the euphonium (baritone horn, tenor tuba, etc.) will find the exhaustive research evident in this volume's pages to be compelling and comprehensive. Contributors are Lloyd Bone, Brian L. Bowman, Neal Corwell, Adam Frey, Marc Dickman, Bryce Edwards, Seth D. Fletcher, Carroll Gotcher, Atticus Hensley, Lisa M. Hocking, Sharon Huff, Kenneth R. Kroesche, R. Winston Morris, John Mueller, Michael B. O'Connor, Eric Paull, Joseph Skillen, Kelly Thomas, Demondrae Thurman, Matthew J. Tropman, and Mark J. Walker.
