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Outcomes in Clinical Trials
The traditional end-points for clinical studies of lung diseases were based on functional parameters. Their value as surrogate markers for disease activity and progression has been increasingly questioned by scientists, carers, regulatory agencies and funding bodies. Novel tools and methods with regard to biomarkers and patient-reported outcomes have made these parameters emerge from their status as interesting secondary end-points and become potential primary outcomes for clinical trials. Nevertheless, their relevance and validity still needs to be proven. This issue of the European Respiratory Monograph describes the current status regarding end-points in all relevant areas of pulmonary medicine.
Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a steadily progressive and ultimately fatal disease of unknown origin. Recent years have seen advances in our understanding of IPF and a number of guidelines have been published. But many questions remain unanswered, particularly surrounding probable versus definite IPF. This Monograph aims to discuss the latest achievements in IPF, and covers key diagnostic issues, staging of the disease, complications and comorbidities, treatment, unmet patient needs and perspectives for the future. This book will be of interest to all clinicians and researchers in this area.
Chronic Obstructive Pulmonary Disease, An Issue of Clinics in Chest Medicine
This issue of Clinics in Chest Medicine, guest-edited by Dr. Gerard Criner and Dr. Bartolome Celli, is focused on Chronic Obstructive Pulmonary Disease. Topics discussed in this issue include but are not limited to: COPD Pathogenesis; Epidemiology of COPD; Host, Gender, and Early Life Factors as Risks for COPD; Alpha One Antitrypsin Deficiency; Lung Function Testing; Assessing Symptom Burden; Chest Imaging in the Diagnosis and Assessment of the Patient with COPD; Biomarkers in the Diagnosis and Assessment of COPD; Asthma/COPD Overlap; Multimorbidity in the Patient with COPD; Definition Causes, Pathogenesis, and Consequences of Exacerbations; Treatment of Acute Exacerbations; Prevention of Exacerbations; Bronchodilators; Benefits and Risks of Inhaled Corticosteroids in COPD; Systemic Medications; Smoking Cessation/Vaccinations; Pulmonary Rehabilitation; Oxygen Therapy/Noninvasive Ventilation; and Interventional and Surgical Therapies for COPD.
SARS, MERS and other Viral Lung Infections
Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Fetal and Neonatal Lung Development
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
Chronic Obstructive Pulmonary Disease Exacerbations
Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat
Peri-operative Management of the Thoracic Patient An Issue of Thoracic Surgery Clinics
This issue of Thoracic Surgery Clinics, guest edited by Drs. Virginia R. Litle and Robert J. Canelli, is devoted to Peri-operative Management of the Thoracic Patient. Drs. Litle and Canelli have assembled expert authors to review the following topics: Preoperative Evaluation of Patients Undergoing Thoracic Surgery; Prehab of the Thoracic Patient; Enhanced Recovery after Thoracic Surgery; Surgical Approaches for Esophagectomy: Open, Minimally Invasive, Robotic. What is the Approach Algorithm?; Intraoperative Anesthetic Management of the Thoracic Surgery Patient; Intraoperative Surgical and Anesthetic Concerns for Robotic Approach to the Thoracic Surgery Patient; Prevention of Postoperative Prolonged Air-leak after Pulmonary Resection; Intraoperative Pre-emptive Prevention of Esophagectomy Complications: Role of Feeding Tubes, Pyloric Drainage Procedures, Anastomotic Buttressing; Interventional Pulmonology: A Brave New World; Pain Management in Thoracic Surgery; Management of Complications after Lung Resections; Management of complications after esophagectomy; and more!
Therapie-Handbuch - Pneumologie
Approx.216 pages
