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All sexually reproducing organisms produce primordial germ cells, a small population of cells that differentiate into gametes of either sex and carry to- potency, an ability to develop into an entire new organism. The study of germ cells has undergone enormous advances in recent years and has entered into an explosive phase of new discoveries with the introduction of transgenic te- nologies and nuclear cloning. Basic knowledge and techniques developed for lower vertebrate and invertebrate systems have facilitated the study of higher vertebrates, including humans. Many experiments that have first been performed on lower vertebrates provided the tools and strategies that could later be applied...
The development of miniaturized systems for chemical and biochemical analysis has grown to the point where lab-on-a-chip devices are now important enabling tools in a diverse array of application areas. As the size of these systems continues to shrink, details of the micro- and nanoscale phenomena associated with their construction and operation must be considered. This book focuses on materials and engineering aspects of lab-on-a-chip devices and the application of microfluidics to materials synthesis. A microfabricated fluidic system integrating biological sample treatment and detection on a single chip offers the promise of low-cost, rapid and high-performance analysis. These devices can perform high-throughput biochemical assays for drug discovery and provide portability for point-of-care diagnostics and biothreat monitoring. Topics include: frontiers in lab-on-a-chip research; materials for lab-on-a-chip; materials synthesis on chip; cell manipulation and biomimetics on chip; porous materials in lab-on-a-chip; sensing and detection on chip - molecular level; sensing and detecting on chip - cells and particles; and sensing and detection on chip - DNA.
Having spent his whole life in the same backyard, Henry has grown accustomed to never migrating. He hardly ever thinks about traveling the world. Instead, Henry occupies himself with being the caretaker of his sick sister, Hanna, spending time with his friends Jay-Jay and Stella, and reading about the world. But when Hanna gives Henry a list of items that could possibly cure her bird disease, he is forced to see her life and his world through new eyes.
"[The] weird, beautiful, unapologetically apocalyptic Last Policeman trilogy is one of my favorite mystery series."—John Green, author of The Fault in Our Stars and Paper Towns Winner of the 2013 Edgar® Award Winner for Best Paperback Original! What’s the point in solving murders if we’re all going to die soon, anyway? Detective Hank Palace has faced this question ever since asteroid 2011GV1 hovered into view. There’s no chance left. No hope. Just six precious months until impact. The Last Policeman presents a fascinating portrait of a pre-apocalyptic United States. The economy spirals downward while crops rot in the fields. Churches and synagogues are packed. People all over the wo...
James Byrne's The Gatekeeper introduces Dez Limerick in the most anticipated thriller in years. A highly trained team of mercenaries launches a well-planned, coordinated attack on a well-guarded military contractor - but they didn't count on one thing, the right man being in the wrong place at the right time. Desmond Aloysius Limerick (“Dez” to all) is a retired mercenary, and enthusiastic amateur musician, currently in Southern California, enjoying the sun and sitting in on the occasional gig, when the hotel he's residing at falls under attack. A skilled team attempts to kidnap the Chief legal counsel of Triton Expeditors, a major military contractor – in fact, Petra Alexandris is the...
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