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From Transplant to Novel Cellular Therapies in Multiple Myeloma
Abstract: Survival of myeloma patients has greatly improved with the use of autologous stem cell transplantation and novel agents, such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies. Compared to bortezomib- and lenalidomide-based regimens alone, the addition of high-dose melphalan followed by autologous transplantation significantly improves progression-free survival, although an overall survival benefit was not observed in all trials. Moreover, follow up of recent trials is still too short to show any difference in survival. In the light of these findings, novel agent-based induction followed by autologous transplantation is considered the standard upfront treat...
Cardiovascular Adverse Events in Modern Myeloma Therapy - Incidence and Risks. A Review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA)
Abstract: Cardiovascular disease in patients with multiple myeloma may derive from factors unrelated to the disease (age, diabetes, dyslipidemia, obesity, prior cardiovascular diseases), related to the disease (cardiac AL-amyloidosis, hyperviscosity, high-output failure, arteriovenous shunting, anemia, renal dysfunction) and/or related to anti-myeloma treatment (anthracyclines, corticosteroids, alkylating agents, immunomodulatory drugs, proteasome inhibitors). Good knowledge of cardiovascular events, effective dose reductions, prevention and management of early and late cardiovascular side effects of chemotherapeutic agents are essential in current clinical practice. Myeloma experts are obliged to carefully balance the efficacy and toxicity of drugs for each individual patient. This review summarizes current data and novel insights into cardiovascular adverse events of today's anti-myeloma treatment, focusing on carfilzomib, as a starting point for developing consensus recommendations on preventing and managing cardiovascular side effects in patients with multiple myeloma
Endoplasmic Reticulum Stress and Inhibition of Apoptotic Caspases Regulate the Life-span of Short-lived Plasma Cells
Plasma cells are the terminally differentiated effector cells of the humoralimmune system. The majority of plasma cells are short-lived and undergoprogrammed cell death in the form of apoptosis after few days of intensiveimmunoglobulin secretion. Despite potentially wide-ranging implications forinfection control, auto-immunity, and plasma cell dyscrasias, the mechanismsthat govern the initiation and execution of plasma cell apoptosis are poorlyunderstood. In this study, it was found that a sharp increase in endoplasmicreticulum (ER) stress and a substantially decreased tolerance to survive ERstress occur in plasma cells that have completed differentiation and begin toundergo apoptosis. Caspa...
Cancer Research
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Brain Inflamed
From renowned integrative family physician Dr Kenneth Bock, a groundbreaking approach to understanding and treating mental health among adolescents and teens. Over the past decade, the number of 12- to 17-year-olds suffering from mental health disorders has more than doubled. While adolescents and teens are notorious for mood swings and rebellion, parents today are navigating new terrain as their children are increasingly at risk of struggling with a mental health issue. But the question remains: What is causing this epidemic of illness? In Brain Inflamed, acclaimed integrative doctor Dr Kenneth Bock shares a revolutionary new view of adolescent and teen mental health - one that suggests man...
Organosilicon Chemistry I
Do you need to know what's new in organosilicon chemistry? This book provides in-depth coverage of the latest developments in this interdisciplinary and fast-evolving field: - selectivity and reactivity of organosilicon compounds - new synthetic applications - structure and bonding - applications in materials and polymer science Written by leading experts, this book is a well-referenced and critical overview of modern silicon chemistry. 'I recommend this book to the student and the practitioner in this new, very different, and very exciting field'. Eugene G. Rochow /Harvard University
Organosilicon Chemistry V
Never Change a winning team. The fifth volume in this renowned series retains the established and successful concept: Leading experts from academia and industry present a comprehensive and detailed overview of the latest results in organosilicon chemistry. Synthesis and characterization of new organosilicon compounds Applications in polymer and materials science Summary of the latest research results The result is a unique collection of first-hand information, vital for every expert working in this field. From the contents: Reactions of Silicon Atoms- An Access to Unusual Molecules New Reactions of Stable Silylenes Synthesis and Chemistry of Some Bridged Silicocations Synthesis of a Highly E...
Das entzündete Gehirn – wenn der Körper die Seele krank macht
Depressionen, Zwangsstörungen oder Angstzustände – jedes Jahr sind mehr Jugendliche von psychischen Erkrankungen betroffen. Die Ursachen werden meist im familiären und schulischen Umfeld gesucht. Doch diese Herangehensweise greift zu kurz, wie der integrative Mediziner Dr. Kenneth Bock zeigt, der einen ganzheitlichen Ansatz vertritt. Die psychischen Leiden können nämlich auch eine körperliche Ursache haben. So hat er herausgefunden, dass Entzündungen im Gehirn dabei eine wichtige Rolle spielen. Sind das Immunsystem oder das Mikrobiom durch Autoimmunerkrankungen, das Leaky-Gut-Syndrom oder eine Nebennierenschwäche aus dem Gleichgewicht geraten, kann das zu entzündlichen Reaktionen ...
Что не так с подростками? Как микробиота влияет на психику наших детей
Подростковый возраст печально известен своими перепадами настроения и бунтарством, что является огромной «головной болью» для родителей. В своей книге Кеннет Бок предлагает революционно новый взгляд на психическое здоровье детей и подростков, который предполагает, что многие психические расстройства, наиболее распространенные среди этой возрастной категории (различного род...
