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This proceedings book presents the latest research findings, and theoretical and practical perspectives on innovative methods and development techniques related to the emerging areas of Web computing, intelligent systems and Internet computing. The Web has become an important source of information, and techniques and methodologies that extract quality information are of paramount importance for many Web and Internet applications. Data mining and knowledge discovery play a key role in many of today's major Web applications, such as e-commerce and computer security. Moreover, Web services provide a new platform for enabling service-oriented systems. The emergence of large-scale distributed com...
Psychopharmacology, Volume 2: Preclinical Psychopharmacology presents the mechanism of action of antidepressant drugs and neuroleptics. This book discusses the significance of the interaction between various neurotransmitter system in both biochemical and functional consequences of repeated drug administration. Organized into 12 chapters, this volume begins with an overview of the effects of antidepressant drugs on norepinephrine metabolism. This text then discusses the different aspects of monoamine oxidase and its inhibitors. Other chapters consider the mechanism of action of lithium, which requires consideration of some of the general characteristics of periodic behavior. This book discusses as well the preclinical aspects of tranquilizers, particularly those dealing with benzodiazepines and non-benzodiazepines acting through the benzodiazepine receptor. The final chapter deals with the various behavioral and electrophysiological effects of cocaine in animals, which presumably reflect both local anesthetic properties and action on monoamine mechanisms. This book is a valuable resource for neuropharmacologists and practicing psychiatrists.
From 1964 to 1966, Carlos Caggiani travelled to 26 countries on a 1947 Indian Chief motorcycle with hardly a penny to his name. At 24 years of age, he embarked on the adventure of a lifetime. He spent time with everyone from poor natives in the Andes mountains, to rich families in the United States. He crossed rivers without bridges, suffered famine, intense heat and cold, guided his motorcycle through rain and snow storms, rode on dirt and cobblestone roads, was chased by the FBI, was shot at in Bolivia during a revolutionary war, and had a serious accident due to a mechanical failure in Panama that left him hospitalized for 17 days. The experiences in this book demonstrate a human being's tenacity and triumph in the face of adversity, and shows that anything is possible. There is always something more just beyond the horizon...and as the horizon expands, our limits disappear.