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All new chemical entities that are produced have to be carefully evaluated in te=s of toxicity. Efforts are continuously being made to improve test procedures so that predictions of toxicity can be made earlier and more accurately. Predicting toxicity is an important part of improving safety assessment, but for this, simplified methods are always demanded. The liver is a frequent target of xenobiotic-induced toxicity and it is of great importance to assess potential hepatotoxicity. Derived from the liver, microsomes retain the metabolic properties of the liver, the organ largely responsible for drug metabolism. This thesis has addressed the development of rapid and inexpensive biosensors for...
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