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The Laboratory Mouse
"Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse"--Provided by publisher.
Unorganized Religion: Pentecostalism and Secularization in Denmark, 1907-1924
Two phenomena profoundly changed the shape of Christendom in the twentieth century: the rise of secularism in Europe, and the rise of Pentecostalism elsewhere. This book investigates the impact of an emerging secular culture on the early Pentecostal movement, using previously unpublished data to build its case study on Denmark. The first Pentecostals were idealists who sought to influence the existing churches from within, but eventually this approach gave way to the more successful strategy of forming separate Pentecostal churches. The insights found herein apply to all religious minorities who seek to adapt to an inhospitable context.
Legal Agreements on Smart Contract Platforms in European Systems of Private Law
Blockchains and smart contracts are emerging technologies that pose unique challenges for legal systems. This book outlines the extent to which these new and innovative technologies could have potentially disruptive effects on contract law in Europe. It does so through a comparative, three-part analysis of the recognisability and effects of smart contracts in European legal systems. First of all, in light of the technologies’ transboundary nature, the book employs a comparative approach, considering French law, German law, English law, and Dutch law to analyse the impact on the different systems of contract law. While doing so, it also addresses the formation, interpretation, and vitiation...
The Multiple Therapeutic Targets of A20
This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target.
Cytokines in Animal Health and Disease
This work offers comprehensive, up-to-date coverage of cytokine biology in veterinary and agricultural species, describing the role of cytokines in physiological and pathological processes. It addresses recent advances and new information on the function of cytokines in reproduction, detoxification of xenobiotics, growth modulation and other areas, and discusses the approaches to and pitfalls of studying cytokines in animals.
Yearbook of Intensive Care and Emergency Medicine 1992
The Yearbook 1992 continues one part of the tradition established by the publication of updates. The Update Series itself will continue with several volumes being published per year on topical special issues. The Yearbookcompiles the most recent, widespread developments of clinical research and practice in one comprehensive reference book. It is addressed to everyone involved in cardiology, internal medicine, anesthesia, intensive care, surgery, pediatrics and emergency medicine.
Cytotoxic Payloads for Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin (Mylotarg™) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages in...
Transcription Factors
With contributions by numerous experts
The Biochemistry of the Nucleic Acids
When the first edition of this book was published in 1950, it set out to present an elementary outline of the state of knowledge of nucleic acid biochemistry at that time and it was the first monograph on the subject to appear since Levene's book on Nucleic Acids in 1931. The fact that a tenth edition is required after thirty five years and that virtually nothing of the original book has been retained is some measure of the speed with which knowledge has advanced in this field. As a result of this vast increase in information it becomes increasingly difficult to fulfil the aims of providing an introduction to nucleic acid biochemistry and satisfying the requirements of advanced undergraduate...
Lloyd's Register Sail Numbers of Racing Yachts 1968
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
