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Brewing Science
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Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
2 The free internal Ca+ concentration in human red cells is set according to the leak 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).
Drug Discovery
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contribut...
Defeat Is the Only Bad News
A Rwandan proverb says “Defeat is the only bad news.” For Rwandans living under colonial rule, winning called not only for armed confrontation, but also for a battle of wits—and not only with foreigners, but also with each other. In Defeat Is the Only Bad News Alison Des Forges recounts the ambitions, strategies, and intrigues of an African royal court under Yuhi Musinga, the Rwandan ruler from 1896 to 1931. These were turbulent years for Rwanda, when first Germany and then Belgium pursued an aggressive plan of colonization there. At the time of the Europeans’ arrival, Rwanda was also engaged in a succession dispute after the death of one of its most famous kings. Against this backdr...
Antithrombotics
A number of exciting new developments have occurred during the last few years concerning the platelet-vessel wall interaction. Although they may be obvious and clear to the specialist in the field, for the clinician the area has become rather confusing. Time has come to review current knowledge on the pathophysiology of the platelet-vessel wall interaction and show how this knowledge can constitute the rationale for pharmacotherapeutic interventions. A symposium was organized in Antwerp during which a number of outstanding speakers gave an overview of what is new on a particular topic and how this information can be translated to possible clinical applications. The proceedings of the symposi...
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Orthodontic Pearls
Orthodontic Pearls: A Selection of Practical Tips and Clinical Expertise synthesizes a wealth of information gleaned from clinical and administrative experiences in orthodontic practice. The administration and running of an orthodontic practice is not often taught extensively or formally in most schools. This book fills that gap by providing tips,
