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Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contribut...
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This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29 -Aprill, 1989. This meeting, held under the co-sponsorship of the Serotonin Club and the Fondazione Giovanni Lorenzini, represents the first attempt to bring together scientists fascinated by the complexity of the action of 5-hydroxytryptamine throughout the body and in various species. Hence this volume provides the reader with the unique overview of the sources, effects, receptors, physiological actions and pathological role of Serotonin. As such it will be of interest not only to the perso...
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
A Rwandan proverb says “Defeat is the only bad news.” For Rwandans living under colonial rule, winning called not only for armed confrontation, but also for a battle of wits—and not only with foreigners, but also with each other. In Defeat Is the Only Bad News Alison Des Forges recounts the ambitions, strategies, and intrigues of an African royal court under Yuhi Musinga, the Rwandan ruler from 1896 to 1931. These were turbulent years for Rwanda, when first Germany and then Belgium pursued an aggressive plan of colonization there. At the time of the Europeans’ arrival, Rwanda was also engaged in a succession dispute after the death of one of its most famous kings. Against this backdr...
A number of exciting new developments have occurred during the last few years concerning the platelet-vessel wall interaction. Although they may be obvious and clear to the specialist in the field, for the clinician the area has become rather confusing. Time has come to review current knowledge on the pathophysiology of the platelet-vessel wall interaction and show how this knowledge can constitute the rationale for pharmacotherapeutic interventions. A symposium was organized in Antwerp during which a number of outstanding speakers gave an overview of what is new on a particular topic and how this information can be translated to possible clinical applications. The proceedings of the symposi...
Orthodontic Pearls: A Selection of Practical Tips and Clinical Expertise synthesizes a wealth of information gleaned from clinical and administrative experiences in orthodontic practice. The administration and running of an orthodontic practice is not often taught extensively or formally in most schools. This book fills that gap by providing tips,