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Drugs on Trial
Experimental pharmacology is often portrayed as a creation of the nineteenth century, the age of the sciences in medicine. This book demonstrates that the basic methodology of the field, including chemical analysis, in vitro testing, animal experimentation and human research, was already developed in the course of the seventeenth and eighteenth centuries. Putting remedies on trial was stimulated by the challenge to Galenism through new chemical, mechanical and vitalist concepts of disease, by the import of exotic drugs and the flourishing trade with secret medicines. The book describes the main issues of eighteenth-century pharmacology and therapeutics and provides detailed case studies of three key areas: lithontriptics (remedies against urinary stones), opium, and Peruvian bark (quinine). It shows how pharmacological knowledge and therapeutic change were promoted in medical centres of the time, such as Edinburgh, London, Paris, Halle and Göttingen. Yet it also reveals how by publication of medical case histories many otherwise little-known practitioners contributed to this scientific enterprise as well.
Conduct of Harold Louderback, U.S. District Judge, Northern District of California
Committee Serial No. 15. Hearings were held in San Francisco, Calif.
The Garden
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The Oxford Book of Scottish Short Stories
From tales of the supernatural to pungent social realism, and from the humorous to the disturbing, whether rural or urban, this anthology shows the vitality of the Scottish short story.Douglas Dunn's eclectic selection displays the marvellous range of Scottish story-telling, beginning with three early traditional tales, and including a wealth of writers from the last three centuries: amongst them Sir Walter Scott, Robert Louis Stevenson, J. M. Barrie, Violet Jacob, Neil Gunn, Eric Linklater, Alasdair Gray, James Kelman, and younger talents such as Ronald Frame, Janice Galloway, and A. L. Kennedy.
Existentialist Criminology
Existentialist Criminology captures an emerging interest in the value of existentialist thought and concepts for criminological work on crime, deviance, crime control, and criminal justice. This emerging interest chimes with recent social and cultural developments - as well as shifts in their theoretical consideration - that are oriented around contingency and unpredictability. But whilst these conditions have largely been described and analysed through the lens of complexity theory, post-structuralist theory and postmodernism, there exploration by critical criminologists in existentialist terms offers a richer and more productive approach to the social and cultural dimensions of crime, deviance, crime control and, more broadly, of regulation and governance. Covering a range of topics that lend themselves quite naturally to existentialist analysis - crime and deviance as becoming and will, the existential openness of symbolic exchange, the internal conversations that take place within criminal justice practices, and the contingent and finite character of resistance - the contributions to this volume set out to explore a largely untapped reservoir of critical potential.
Preclinical Development Handbook
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and te...
