Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Tumor-Induced Immune Suppression
This monograph, for the first time, presents a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It discusses a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance. There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in a more or less cohesive structure and how they can help to improve immune response to tumors.
Cancer Immunotherapy
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational...
Sensory Neuropathies
While motor neuropathies and neuronopathies and mixed sensory-motor neuropathies have been met with adequate interest by clinical and basic researchers and physicians, pure sensory neuropathies and neuro nopathies have received comparably less attention, despite of the consider able morbidity they may cause in the individual patient. This prompted us to organize an International Symposium on Sensory Neuropathies which was held in Vienna, September 22-24,1990, as satellite to the International Neuromuscular Congress held one week earlier in Munich, Germany. We were fortunate to have a faculty of experienced authorities in the field as participants. This volume is the proceedings of the sympos...
Emerging Drugs and Targets for Multiple Sclerosis
Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.
Abdominal Sepsis
This book examines in detail the topic of sepsis, with a focus on intra-abdominal sepsis. Particular attention is devoted to source control in the management of the infection, antimicrobial therapy and sepsis support, which represent the cornerstones of treating patients with this problem. The importance of a multidisciplinary approach is highlighted not only by the instructive and informative sections on the acute manifestations of appendicitis, cholecystitis, and cholangitis, perforations and diverticulitis, Clostridium difficile infection and the role of candida in abdominal sepsis, but also by an extensive discussion of issues including antimicrobial resistance, damage control surgery, p...
Intensive Care for Emergency Surgeons
This book provides the basis needed for a dialogue between intensivists and emergency surgeons regarding the management and monitoring of acute care surgery (ACS) patients who require Intensive Care Unit (ICU) admission. It puts forward a practical approach to the treatment of common emergencies in daily clinical practice, and shares essential information on the treatment and monitoring of hemodynamic, respiratory, metabolic and neurological problems related to acute surgical patients requiring ICU admission. Furthermore, it includes two chapters regarding diagnostic and interventional radiology (fundamentals in daily emergency clinical practice), and addresses important issues such as ethics, mass casualty care, and care in low-resource settings. As such, the book not only offers a valuable guide for all practicing surgeons and intensivists, but is also relevant for residents and fellows who are newcomers to ACS.
The Neurobiology of Disease
Demonstrating the value of interactions between neurology and the basic sciences that underpin it, this volume considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding have been and continue to be made. The coverage boasts an excellent section on the physiology and pathophysiology of central and peripheral nerve fibers and an in-depth view of motor control including the often ignored but vital respiratory movements. Also notable are the chapters on neuronal plasticity, and cell death and axonal regeneration: active areas in neuroscience, where new knowledge will almost certainly revolutionize neurological treatments in years to come.
Ubiquitous Computing and Ambient Intelligence
This book constitutes the refereed proceedings of the 6th International Conference on Ubiquitous Computing and Ambient Intelligence, UCAmI 2012, held in Vitoria-Gasteiz, Spain, in December 2012. The 70 research papers were carefully reviewed and selected from various submissions. The main focus of this book has been to explore how Ambient Intelligence can contribute towards smarter but still more sustainable environments. Beyond sustainable computing the proceedings also include research work describing progress on other key research topics for AmI such as human environment mobile-mediated (through NFC or AR) interaction, artificial intelligence techniques to foster user- and context-aware environment adaptation, future internet trends such as social networks analysis, linked data or crowd-sourcing applied to AmI, internet-connected object ecosystems collaborating to give place to smarter environments.
Pain
This volume provides a comprehensive accounting of pain and its relation to neurology. It is dedicated entirely to the mechanisms and clinical aspects of the subject, and provides a wealth of information on the latest neurobiological and clinical data surrounding the topic. From discussions of the physiology and pathology of the pain pathways from signaling, via spinal cord and supraspinal processing to endogenous pain modulation, users will gain an invaluable reference that provides a new understanding of pain related topics, including cytokines, sex differences, and the autonomic nervous system. Practicing clinicians, internists, surgeons, and those in the fields of psychiatry and gerontol...
Understanding and Predicting the Gulf of Mexico Ocean Dynamics
For the past several years, a number of research programs have funded significant efforts to advance understanding of and forecasting capabilities for the Gulf of Mexico circulation, including the Loop Current, its associated eddies, and abyssal dynamics. One such program is the National Academies’ Understanding Gulf Ocean Systems initiative, which focuses on improving forecasts of the physical dynamics of the open Gulf of Mexico in space and time scales useful for the reduction of risks to offshore energy exploration and production, as well as for other challenges such as forecasting hurricane intensification and managing fisheries. What has been learned, how can this scientific progress be incorporated into operational models, and what are the remaining gaps in knowledge impeding predictive skill?
