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Tumor-Induced Immune Suppression
Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
Tumor-Induced Immune Suppression
This monograph, for the first time, presents a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It discusses a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance. There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in a more or less cohesive structure and how they can help to improve immune response to tumors.
Neutrophils, The: New Outlook For Old Cells
This invaluable volume, written by group of internationally established scientists, presents an overview of the most recent findings on the biology of neutrophils. These cells have become a focus of attention in recent years because of their fascinating biochemistry and molecular biology and their ability to affect the functions of other cells. The book describes, in detail, the molecular events leading to neutrophil activation, migration, microbial killing, production of oxidative radicals and cytokines, and eventually to the death of these cells. It presents new information that has never been discussed in monographs before. It also gives a unique overview of the neutrophil's role in viral diseases, including Aids. Finally, the book describes how to improve the function of neutrophils and use these cells in the treatment of diseases.
Neutrophils, The: New Outlook For Old Cells (2nd Edition)
This is a second edition of the book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been implicated in anti-tumor response. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This book provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration of these cells. It contains unique information on the neutrophil's role in viral infectious diseases and cancer. It also presents the recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases.
Neutrophils, The: New Outlook For Old Cells (3rd Edition)
This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of these cells. Besides that, it contains unique information regarding neutrophils' role in cancer. Finally, this monograph describes recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases./a
The Neutrophils
This invaluable volume, written by group of internationally established scientists, present an overview of the most recent findings on the biology of neutrophils. These cells have become a focus of attention in recent years because of their fascinating biochemistry and molecular biology and their ability to affect the function of other cells. The book describes, in detail, the molecular events leading to neutrophil activation, migration, microbial killing, production of oxidative radicals and cytokines, and eventually to the death of these cells. It presents new information that has never been discussed in monographs before. It also gives a unique overview of the neutrophil's role in vital diseases, including Aids. Finally, the book describes how to improve the function of neutrophils and use these cells in the treatment of diseases.
Immune Mediated Diseases
This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings. The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow.
The Tumor Immunoenvironment
Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
The Cytokine Handbook
The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Expanded to two volumes, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems.
