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Policy Legitimacy, Science and Political Authority
Voters expect their elected representatives to pursue good policy and presume this will be securely founded on the best available knowledge. Yet when representatives emphasize their reliance on expert knowledge, they seem to defer to people whose authority derives, not politically from the sovereign people, but from the presumed objective status of their disciplinary bases. This book examines the tensions between political authority and expert authority in the formation of public policy in liberal democracies. It aims to illustrate and better understand the nature of these tensions rather than to argue specific ways of resolving them. The various chapters explore the complexity of interactio...
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Fragment-based Drug Discovery
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
VA Hospitals
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Heaven on Earth
'What Fauber does well is humanize these four residents of the pantheon of science... The story is seldom less than fascinating. A readable, enjoyable contribution to the history of science.' - Kirkus An intimate examination of a scientific family - that of Nicolaus Copernicus, Tycho Brahe, Johannes Kepler and Galileo Galilei. Fauber juxtaposes their scientific work with insight into their personal lives and political considerations, which shaped their pursuit of knowledge. Uniquely, he shows how their intergenerational collaboration made the scientific revolution possible. These brave scientists called each other 'brothers', 'fathers' and 'sons', and laid the foundations of modern science through familial co-work. And though the sixteenth century was far from an open society for women, there were female pioneers in this 'family' as well, including Brahe's sister Sophie, Kepler's mother, and Galileo's daughter. Filled with rich characters and sweeping historical scope, this book reveals how the strong connections between these pillars of intellectual history moved science forward.
Multidisciplinary Management of Chronic Pain
"This book is a 'must have' resource in every physician/clinician practice setting."--Martin Grabois, M.D., Professor of PM&R, Baylor College of Medicine, Houston,TX. Dr. Vasudevan draws upon an accumulated reservoir of clinical expertise to provide readers with an up-to-date and highly readable guide to multidisciplinary pain management. . . . If only this book was available years ago"--Francis J. Keefe, PhD. Professor of Psychology, Psychiatry and Anesthesiology, Duke University, Durham, NC. This practical volume brings multidisciplinary innovations to the treatment of chronic pain. It argues expertly for the benefits of a biopsychosocial approach over current pain treatments more suited t...
Army Register
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