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Drink, Drugs and Dependence
At a world level addiction and the fall-out from substance use is affecting more and more lives. Professionals are increasingly being confronted with puzzling, multifaceted aspects of substance use, whether they work in a clinic, the laboratory or the community. If you are a member of any caring profession, sooner or later you will encounter problems caused by drugs, alcohol and tobacco. In order to understand substance use and substance users, no single discipline can provide all the answers. In a novel way, this book integrates biological science, social science and clinical experience. It draws together contributions from experts in these diverse and rapidly growing fields, providing the reader with a deeper capacity to engage with problems effectively. Drink, Drugs and Dependence includes thought-provoking examples, illustrations and test questions to support problem-based learning. Designed to be read consecutively or as a reference text, it will be a welcome resource for all those working in the field of addiction.
Endoplasmic Reticulum Stress in Health and Disease
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegen...
Neurodegenerative Diseases
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Current Catalog
First multi-year cumulation covers six years: 1965-70.
In Situ Hybridization: Medical Applications
In situ hybridization has developed as a means of localizing specific DNA and RNA sequences within tissues. The great strength of this approach is the ability to relate the distribution of specific nucleic acids with cell structures and the protein products of the target gene by means of immunohistochemistry. Complementary DNA, RNA or oligonucleotide probes, suitably labelled, are hybridized to specific DNA or RNA targets within tissues. The spatial information thus obtained has contributed greatly to our understanding of such diverse areas of research as gene mapping, viral infection, cytogenetics, protein synthesis, prenatal diagnosis and tissue grafting. This book is not intended as another recipe book, although it does describe theoretical and practical aspects of the technology. Rather, the authors critically describe the contribution made by in situ hybridization to specific areas of medical research.
The Age of Anxiety
Anxious Americans have increasingly pursued peace of mind through pills and prescriptions. In 2006, the National Institute of Mental Health estimated that 40 million adult Americans suffer from an anxiety disorder in any given year: more than double the number thought to have such a disorder in 2001. Anti-anxiety drugs are a billion-dollar business. Yet as recently as 1955, when the first tranquilizer -- Miltown -- went on the market, pharmaceutical executives worried that there wouldn't't be interest in anxiety-relief. At mid-century, talk therapy remained the treatment of choice. But Miltown became a sensation -- the first psychotropic blockbuster in United States history. By 1957, America...
