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Signalling within and between cells is an essential part of many biological processes, from the development of the body to the activity of our immune system. Cell Signalling, Third Edition, presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms before examining how these components come together to create signalling pathways, which are so crucial to the survival of many living organisms. The text is enhanced by two-color artwork and 3-D protein models. A Companion Website provides resources for students and instructors.
He was a rich, powerful aristocrat, a merchant king who loved English culture and fashion, and, above all, he was a loyal British subject with ambitions of a lordship and a grand retirement estate in England. There simply was no doubt about it: John Hancock was the least likely man in Boston to start a rebellion. How, then, did this Tory patrician become one of the staunchest supporters of the American Revolution?
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Six months after the Declaration of Independence, the American Revolution was all but lost. A powerful British force had routed the Americans at New York, occupied three colonies, and advanced within sight of Philadelphia. Yet, as David Hackett Fischer recounts in this riveting history, George Washington--and many other Americans--refused to let the Revolution die. On Christmas night, as a howling nor'easter struck the Delaware Valley, he led his men across the river and attacked the exhausted Hessian garrison at Trenton, killing or capturing nearly a thousand men. A second battle of Trenton followed within days. The Americans held off a counterattack by Lord Cornwallis's best troops, then w...