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New Approaches to Classification and Diagnostic Prediction of Breast Cancers
Despite many years of translational research in breast cancer, very few new biomarkers have been implemented for clinical use beyond estrogen receptor, progesterone receptor, and HER2. The main reason is that many promising biomarkers are clinically validated but lack analytical and clinical utility. One explanation is that proper validation of the predictive ability of the biomarker in independent datasets, and with a pre-planned statistical analysis, is not always performed. Thus, there is a need to identify new biomarkers or new ways to subclassify breast cancer patients that are reproducible and easy to implement in the clinical setting but, more importantly, that improve patient’s outcomes.
Engineer Update
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Reproducing Nations
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Re-Mapping Centre and Periphery
Historians often assume a one-directional transmission of knowledge and ideas, leading to the establishment of spatial hierarchies defined as centres and peripheries. In recent decades, transnational and global history have contributed to a more inclusive understanding of intellectual and cultural exchanges that profoundly challenged the ways in which we draw our mental maps. Covering the early modern and modern periods, Re-Mapping Centre and Periphery investigates the asymmetrical and multi-directional structure of such encounters within Europe as well as in a global context. Exploring subjects from the shores of the Russian Empire to nation-making in Latin America, the international team o...
Transnational Spanish Studies
The focus of this book is two-fold. First it traces the expansive geographical spread of the language commonly referred to as Spanish. This has given rise to multiple hybrid formations over time emerging in the clash of multiple cultures, languages and religions within and between great empires (Roman, Islamic, Hispano-Catholic), each with expansionist policies leading to wars, huge territorial gains and population movements. This long history makes Hispanophone culture itself a supranational, trans-imperial one long before we witness its various national cultures being refashioned as a result of the transnational processes associated with globalization today. Indeed, the Spanish language we...
Methods in Breast Cancer
Frontiers in Oncology is delighted to present the Methods in series of article collections. Methods in Breast Cancer will publish high-quality methodical studies on key topics in the field. It aims to highlight recent advances in the field, whilst emphasizing important directions and new possibilities for future inquiries. The Methods in Breast Cancer collection aims to highlight the latest experimental techniques and methods used to investigate fundamental questions in Breast Cancer. Review Articles or Opinion Articles on methodologies or applications including the advantages and limitations of each are welcome. This Research Topic includes technologies and up-to-date methods which help aim to help advance science. Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Public Papers of the Presidents of the United States
"Containing the public messages, speeches, and statements of the President", 1956-1992.
Nanomaterials under Extreme Conditions
Nanomaterials have supported humankind’s advancement, becoming one of the most important industry sectors, and are expected to rise to the top by 2030. However, significant challenges must be overcome, such as the performance and efficiency of the material under different environmental conditions. This book seeks to promote a critical view on using nanomaterials under extreme conditions found in our body, planet, and outer space. Therefore, nanomaterials are covered from multiple points of view, allowing the reader to get an enriching presentation of current knowledge on nanomaterials, limitations, advancements, and applications under extreme conditions.
HER2-Positive Breast Cancer
Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today's available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists. - Covers the diagnosis, treatments and targeted therapies, and management of breast cancers that are HER2-positive. - Contains sections on background and testing, advanced disease, therapeutics, and toxicity considerations. - Includes a timely section on innovative future therapies.
