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CNS Regeneration
CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies. - The first comprehensive, authoritative volume on the topic of CNS regeneration - Reviews current therapeutic approaches - Editors and authors are experts in the field - Appeals to those interested in basic science as well as those concerned with its medical application
A Life Shaken
"I'm flat on my back on a couch that's too short in a windowless room in the bureau. I can't even sit at a computer, much less make a keyboard work. My arms and legs are shaking uncontrollably. Although I am only 53 years old, I have already been struggling with Parkinson's disease for seven years. And right now the disease is winning." So begins Joel Havemann's account of the insidious disease that is Parkinson's. Into his own story, Havemann weaves accessible explanations of how Parkinson's disrupts the brain's circuitry, how symptoms are managed through drugs and surgery, and how people cope with the disease's psychological challenges. The updated paperback edition brings the discussion of treatment options and research thoroughly up to date.
The Year in Neurology 2, Volume 1184
This second volume in The Year in Neurology series focuses on present reviews covering novel approaches to our understanding neurological diseases through both basic science and clinical approaches. A wide-range of topics is covered within this volume, including: vertebrobasilar dolichoectasia neurological nanotechnology neurologic diseases sleep disorders chronic inflammatory diseases NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Neural Transplantation
After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.
Parkinson's Disease
Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neuro...
Cell Therapy
This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with...
Cell Transplantation for Neurological Disorders
Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.
Cell and Gene Therapies for Neurologic Diseases
Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson's, Huntington's, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs. - Summarizes advances in cell and gene therapy for neurological diseases - Describes the therapies available and in development - Includes surgical, ethical, and manufacturing considerations - Identifies best practices for specific neurological diseases - Covers Huntington's, Parkinson's, ALS, Stroke, Demyelination, epilepsy, and more
Restorative Therapies in Parkinson's Disease
In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic.
Principles of Treatment in Parkinson's Disease
This succinct volume offers an up-to-date review and comparison of the treatment options available for Parkinson's disease, and provides evidence-based recommendations on appropriate treatments for specific cases. Offers expert guidance on the best treatment options from authorities in the field. Delivers expert guidance on drug therapies, physical therapies, and surgical interventions. Discusses conditions such as depression ? hallucinations ? cognition ? and sleep disorders. Explores neuroprotection in Parkinson's disease. Provides insights into future therapies.
