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Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Abstract: This primary textbook and reference source provides information on recent developments in allergy and immunology to clinicians and laboratory scientists. Volume I is concerned with basic information on the immunology, physiology, and pharmacologic aspects of allergic disease and includes data on the basic mechanisms involved in allergic disease and the biology of the cell types involved in allergic reactions. Volume II is the clinical science section and covers the essential clinical diagnostic, and therapeutic aspects of allergic disease. These articles are extensively referenced.
Manuscript instructions for 246 English-language biomedical journals. Miscellaneous appendixes, including uniform requirements set up by a committee of editors in 1978.
For much of the twentieth century scientists sought to explain objects and processes by reducing them to their components—nuclei into protons and neutrons, proteins into amino acids, and so on—but over the past forty years there has been a marked turn toward explaining phenomena by building them up rather than breaking them down. This collection reflects on the history and significance of this turn toward “growing explanations” from the bottom up. The essays show how this strategy—based on a widespread appreciation for complexity even in apparently simple processes and on the capacity of computers to simulate such complexity—has played out in a broad array of sciences. They descr...
First multi-year cumulation covers six years: 1965-70.
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