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Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
The second volume in this long-running series presents the usual critical and intensive review chapters divided into five sections but also addresses particular topics of special interest, including drugs and their use, and misuse, among the aged; the nonmedication orientation to treatment of various disorders; the immune system; and clinical procedures in the management of urinary incontinence. As with all the volumes, the contributors represent an international array of leading experts.
Abstract: This primary textbook and reference source provides information on recent developments in allergy and immunology to clinicians and laboratory scientists. Volume I is concerned with basic information on the immunology, physiology, and pharmacologic aspects of allergic disease and includes data on the basic mechanisms involved in allergic disease and the biology of the cell types involved in allergic reactions. Volume II is the clinical science section and covers the essential clinical diagnostic, and therapeutic aspects of allergic disease. These articles are extensively referenced.